Literature summary for 3.5.4.16 extracted from

Chiarini, A.; Armato, U.; Pacchiana, R.; Dal Pra, I.
Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions (2009), Proteomics, 9, 1850-1860.

Search for more literature for 3.5.4.16

Activating Compound

Activating Compound	Comment	Organism	Structure
interferon-gamma	GCH1 expression is strongly induced by a mixture of interleukin-1beta, tissue necrosis factor-alpha, and interferon-gamma released by microglia under brain-damaging conditions	Homo sapiens
interleukin-1beta	GCH1 expression is strongly induced by a mixture of interleukin-1beta, tissue necrosis factor-alpha, and interferon-gamma released by microglia under brain-damaging conditions	Homo sapiens
tissue necrosis factor-alpha	GCH1 expression is strongly induced by a mixture of interleukin-1beta, tissue necrosis factor-alpha, and interferon-gamma released by microglia under brain-damaging conditions	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
astrocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP + H2O	-	Homo sapiens	formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate	-	?

Synonyms

Synonyms	Comment	Organism
GCH1	-	Homo sapiens
GTP cyclohydrolase 1	-	Homo sapiens

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Release 2023.1 (January 2023)