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Literature summary for 3.5.4.16 extracted from

  • Chavan, B.; Beazley, W.; Wood, J.M.; Rokos, H.; Ichinose, H.; Schallreuter, K.U.
    H2O2 increases de novo synthesis of (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin via GTP cyclohydrolase I and its feedback regulatory protein in vitiligo (2009), J. Inherit. Metab. Dis., 32, 86-94.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
H2O2 0.1 mM H2O2 is the optimum concentration for the activation of GTPCHI Homo sapiens
L-phenylalanine feedback regulation via L-phenylalanine Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
H2O2 more than 0.3 mM H2O2 result in a decrease in activity of GTPCHI, the function of the GTP cyclohydrolase I/GTP cyclohydrolase I feedback regulatory protein complex is not affected by H2O2 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
Homo sapiens formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
?

Synonyms

Synonyms Comment Organism
GTP cyclohydrolase I
-
Homo sapiens
GTPCHI
-
Homo sapiens