Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.4.16 extracted from

  • Tatham, A.L.; Crabtree, M.J.; Warrick, N.; Cai, S.; Alp, N.J.; Channon, K.M.
    GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression (2009), J. Biol. Chem., 284, 13660-13668.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.16

Activating Compound

Activating Compound Comment Organism Structure
additional information GTPCH expression is regulated by inflammatory stimuli, in association with reduced expression of GTP cyclohydrolase feedback regulatory protein Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information GTP cyclohydrolase feedback regulatory protein overexpression and knockdown in tet-GCH cells does not alter GTPCH activity or tetrahydrobiopterin levels, and GTPCH-specific knockdown in sEnd.1 endothelial cells has no effect on GTP cyclohydrolase feedback regulatory protein Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
 Mus musculus
-
liver
-
 Mus musculus
-
NIH-3T3 cell transfected with a tet-off plasmid and a plasmid encoding human GCH1, the stable clone is named tet-GCH cell Mus musculus
-
sEnd-1 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Mus musculus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?

Synonyms

Synonyms Comment Organism
GTP cyclohydrolase I
-
 Mus musculus
GTPCH
-
 Mus musculus