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Literature summary for 3.5.4.16 extracted from

  • Bowling, K.M.; Huang, Z.; Xu, D.; Ferdousy, F.; Funderburk, C.D.; Karnik, N.; Neckameyer, W.; O'Donnell, J.M.
    Direct binding of GTP cyclohydrolase and tyrosine hydroxylase: regulatory interactions between key enzymes in dopamine biosynthesis (2008), J. Biol. Chem., 283, 31449-31459.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.16

Activating Compound

Activating Compound Comment Organism Structure
additional information GTP cyclohydrolase I is activated by phosphorylation with protein kinase C or A Drosophila melanogaster

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3)pLysS cells Drosophila melanogaster

Inhibitors

Inhibitors Comment Organism Structure
tetrahydrobiopterin
-
 Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Drosophila melanogaster GTP cyclohydrolase I stimulates tyrosine hydroxylase activity by increasing the maximal velocity of the enzyme and fails to block the feedback inhibition of tyrosine hydroxylase by dopamine ?
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate precipitation, Ni-NTA column chromatography, and Sephacryl S-300HR gel filtration Drosophila melanogaster

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Drosophila melanogaster formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
additional information GTP cyclohydrolase I stimulates tyrosine hydroxylase activity by increasing the maximal velocity of the enzyme and fails to block the feedback inhibition of tyrosine hydroxylase by dopamine Drosophila melanogaster ?
-
 ?

Synonyms

Synonyms Comment Organism
GTP cyclohydrolase I
-
 Drosophila melanogaster
GTPCH
-
 Drosophila melanogaster