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Literature summary for 3.5.4.16 extracted from

  • Wang, S.; Xu, J.; Song, P.; Wu, Y.; Zhang, J.; Chul Choi, H.; Zou, M.H.
    Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure (2008), Hypertension, 52, 484-490.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.16

Inhibitors

Inhibitors Comment Organism Structure
2,4-Diamino-6-hydroxypyrimidine
-
 Bos taurus
2,4-Diamino-6-hydroxypyrimidine
-
 Mus musculus
N-acetyl-serotonin
-
 Bos taurus
N-acetyl-serotonin
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus GTPCH1 via tetrahydrobiopterin maintains normal blood pressure and endothelial function in vivo by preserving nitric oxide synthesis by endothelial NO synthase ?
-
 ?
additional information Bos taurus GTPCH1 via tetrahydrobiopterin maintains normal blood pressure and endothelial function in vivo by preserving nitric oxide synthesis by endothelial NO synthase ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
 Mus musculus
-
aorta
-
 Bos taurus
-
aortic endothelial cell
-
 Mus musculus
-
aortic endothelial cell
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Mus musculus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
GTP + H2O
-
 Bos taurus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
additional information GTPCH1 via tetrahydrobiopterin maintains normal blood pressure and endothelial function in vivo by preserving nitric oxide synthesis by endothelial NO synthase Mus musculus ?
-
 ?
additional information GTPCH1 via tetrahydrobiopterin maintains normal blood pressure and endothelial function in vivo by preserving nitric oxide synthesis by endothelial NO synthase Bos taurus ?
-
 ?

Synonyms

Synonyms Comment Organism
GTP cyclohydrolase 1
-
 Mus musculus
GTP cyclohydrolase 1
-
 Bos taurus
GTPCH1
-
 Mus musculus
GTPCH1
-
 Bos taurus
guanosine triphosphate cyclohydrolase 1
-
 Mus musculus
guanosine triphosphate cyclohydrolase 1
-
 Bos taurus