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Literature summary for 3.5.4.16 extracted from
- Expression of one isoform of GTP cyclohydrolase I coincides with the larval black markings of the swallowtail butterfly, Papilio xuthus (2006), Insect Biochem. Mol. Biol., 36, 63-70.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | Papilio xuthus | the enzyme produces the cofactor tetrahydrobiopterin essential for activities of tyrosine hydroxylase and DOPA decarboxylase | formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate | - |
? |  |
| additional information | Papilio xuthus | isozyme GTPCHIa activity is involved in formation of the black markings on the larva during fourth ecdysis, pigmentation pathway overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Papilio xuthus | - |
swallowtail butterfly | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epidermis | larval, expression pattern of GTPCH isozymes Ia and Ib, overview | Papilio xuthus | - |
| larva | the black markings on the larva during fourth ecdysis are involving the GTPCHI activity | Papilio xuthus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | - |
Papilio xuthus | formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate | - |
? | |
| GTP + H2O | the enzyme produces the cofactor tetrahydrobiopterin essential for activities of tyrosine hydroxylase and DOPA decarboxylase | Papilio xuthus | formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate | - |
? | |
| additional information | isozyme GTPCHIa activity is involved in formation of the black markings on the larva during fourth ecdysis, pigmentation pathway overview | Papilio xuthus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GTPCHI | - |
Papilio xuthus |
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Release 2023.1 (January 2023)
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