Application | Comment | Organism |
---|---|---|
biotechnology | creation of a phenylalanine sink by transgenic overexpression of phenylalnine hydroxylase and GTP cyclohydrolase I in the skin to reduce high phenylalanine concentrations in the blood in phenylketonuria metabolic disease | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of transgenic mice overexpressing the enzyme specifically in the skin together with phenylalanine hydroxylase, the clearance of phenylalanine from blood is increased in transgenic mice, measured in those with phenylketonuria, mice genotyping, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Mus musculus | the enzyme synthesizes the cofactor for the reaction of the phenylalanine hydroxylase | formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Mus musculus | formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate | - |
? | |
GTP + H2O | the enzyme synthesizes the cofactor for the reaction of the phenylalanine hydroxylase | Mus musculus | formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GTP-CH | - |
Mus musculus |