Activating Compound | Comment | Organism | Structure |
---|---|---|---|
lipolysaccharide | commercially isolated from Escherichia coli serotype 026:B6, activates and upregulates the enzyme in adipose tissue, but in cultured 3T3-L1 adipocytes lipolysaccharide addition only increases the enzyme expression level in presence of TNFalpha and interferon gamma, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Mus musculus | the enzyme is rate limiting in the tetrahydrobiopterin biosynthesis in adipose tissue, overview | formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q05915 | precursor; C3H/HeN and C3H/HeJ mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
3T3-L1 cell | adipocyte cell line | Mus musculus | - |
brown adipose tissue | - |
Mus musculus | - |
additional information | GCH expression patterns | Mus musculus | - |
white adipose tissue | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
tissue dependent enzyme activity and effects of cytokines | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Mus musculus | formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate | - |
? | |
GTP + H2O | the enzyme is rate limiting in the tetrahydrobiopterin biosynthesis in adipose tissue, overview | Mus musculus | formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GCH | - |
Mus musculus |
GCH1 | - |
Mus musculus |