Literature summary for 3.5.4.16 extracted from

Suzuki, T.; Ohye, T.; Inagaki, H.; Nagatsu, T.; Ichinose, H.
Characterization of wild-type and mutants of recombinant human GTP-cyclohydrolase I: Relationship to etiology of dopa-responsive dystonia (1999), J. Neurochem., 73, 2510-2516.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
G201E	no activity at 0.1 mM GTP	Homo sapiens
M211I	low activity at 0.1 mM GTP	Homo sapiens
R184H	very low activity at 0.1 mM GTP	Homo sapiens
R88W	very low activity at 0.1 mM GTP	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
expression of wild-type and mutant proteins in Escherichia coli	Homo sapiens

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP + H2O	-	Homo sapiens	formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate	-	?

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Release 2023.1 (January 2023)