Literature summary for 3.5.4.12 extracted from

  • Jansen, R.S.; Rosing, H.; Schellens, J.H.; Beijnen, J.H.
    Deoxyuridine analog nucleotides in deoxycytidine analog treatment: secondary active metabolites? (2011), Fundam. Clin. Pharmacol., 25, 172-185.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
dCMP allosterically increases dCMPD activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
dGMP potent competitive inhibitor Homo sapiens
dTTP inhibits dCMPD by allosteric interaction Homo sapiens
dUMP potent competitive inhibitor Homo sapiens
GMP potent competitive inhibitor Homo sapiens
additional information monophosphates of deoxycytidine analogs nucleosides in the L-conformation (e.g. apricitabine, lamivudine, and emtricitabine) and dideoxycytidine do not act as inhibitors of dCMPD Homo sapiens
tetrahydrodeoxyuridine
-
Homo sapiens
TTP inhibits dCMPD by allosteric interaction Homo sapiens
zebularine
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dCMP + H2O Homo sapiens
-
dUMP + NH3
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cytidine monophosphate is not a good substrate for dCMPD. Monophosphates of deoxycytidine analogs nucleosides in the L-conformation (e.g. apricitabine, lamivudine, and emtricitabine) and dideoxycytidine do not act as substrates of dCMPD Homo sapiens ?
-
?
dCMP + H2O
-
Homo sapiens dUMP + NH3
-
?
ara-CMP + H2O fair substrate Homo sapiens ara-UMP + NH3
-
?
(+)-FTCMP + H2O
-
Homo sapiens ?
-
?
2',3'-dideoxy-5-fluoro-3'-thiacytidine + H2O good substrate Homo sapiens ?
-
?
5-aza-dCMP + H2O
-
Homo sapiens 5-aza-dUMP + NH3
-
?
PSI-6130-MP + H2O weak substrate Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
deoxycytidine monophosphate deaminase
-
Homo sapiens
dCMPD
-
Homo sapiens

General Information

General Information Comment Organism
metabolism dCMPD is pivotal in deoxyuridine analogs nucleotide formation Homo sapiens