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Literature summary for 3.5.4.12 extracted from

  • McIntosh, E.M.; Haynes, R.H.
    Isolation of a Saccharomyces cerevisiae mutant strain deficient in deoxycytidylate deaminase activity and partial characterization of the enzyme (1984), J. Bacteriol., 158, 644-649.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
dCTP severalfold activation, activation requires presence of Mg2+ Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information preliminary kinetic studies and kinetic data Saccharomyces cerevisiae
1
-
dCMP
-
Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required for activation by dCTP, Mg2+ in the absence of dCTP: no effect Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dCMP + H2O Saccharomyces cerevisiae deoxycytidine nucleotides are shunted into dTMP biosynthetic pathway via reaction catalyzed by dCMP deaminase dUMP + NH3
-
?

Organism

Organism UniProt Comment Textmining
no activity in Escherichia coli
-
-
-
no activity in Salmonella typhimurium
-
-
-
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial, strain ACM-13 Saccharomyces cerevisiae

Storage Stability

Storage Stability Organism
-70°C Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-bromo-dCMP + H2O very poor substrate Saccharomyces cerevisiae 5-bromo-dUMP + NH3
-
?
5-chloro-dCMP + H2O very poor substrate Saccharomyces cerevisiae 5-chloro-dUMP + NH3
-
?
5-fluoro-dCMP + H2O very poor substrate Saccharomyces cerevisiae 5-fluoro-dUMP + NH3
-
?
5-iodo-dCMP + H2O very poor substrate Saccharomyces cerevisiae 5-iodo-dUMP + NH3
-
?
5-methyl-dCMP + H2O 5-methyl-dCMP: very poor substrate Saccharomyces cerevisiae 5-methyl-dUMP + NH3
-
?
dCMP + H2O highly specific for dCMP Saccharomyces cerevisiae dUMP + NH3
-
?
dCMP + H2O deoxycytidine nucleotides are shunted into dTMP biosynthetic pathway via reaction catalyzed by dCMP deaminase Saccharomyces cerevisiae dUMP + NH3
-
?
additional information substrate specificity Saccharomyces cerevisiae ?
-
?
additional information halogenated deoxycytidylates: very poor substrates Saccharomyces cerevisiae ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 9.5 broad pH optimum Saccharomyces cerevisiae
8.2
-
assay at Saccharomyces cerevisiae