Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | low-dose etoposide enhances telomerase-dependent adenovirus-mediated cytosine deaminase gene therapy through augmentation of adenoviral infection and transgene expression in a syngeneic bladder tumor model, overview | Escherichia coli |
Application | Comment | Organism |
---|---|---|
medicine | the enzyme is useful in gene therapy for treatment of cancer, bladder tumor model, overview | Escherichia coli |
Cloned (Comment) | Organism |
---|---|
expression of the recombinant fusion gene from adenoviral vector under control of the human telomerase reverse transcriptase promoter in murine syngeneic MBT-2 bladder tumor cells, overview | Escherichia coli |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a fusion gene in an adenoviral vector comprising human telomerase reverse transcriptase promoter, and cytosine deaminase from Escherichia coli | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine + H2O | Escherichia coli | - |
uracil + NH3 | - |
? | |
additional information | Escherichia coli | low-dose etoposide enhances telomerase-dependent adenovirus-mediated cytosine deaminase gene therapy through augmentation of adenoviral infection and transgene expression in a syngeneic bladder tumor model, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-fluorocytosine + H2O | - |
Escherichia coli | 5-fluorouracil + NH3 | - |
? | |
cytosine + H2O | - |
Escherichia coli | uracil + NH3 | - |
? | |
additional information | low-dose etoposide enhances telomerase-dependent adenovirus-mediated cytosine deaminase gene therapy through augmentation of adenoviral infection and transgene expression in a syngeneic bladder tumor model, overview | Escherichia coli | ? | - |
? |