Literature summary for 3.5.4.1 extracted from

Rehemtulla, A.; Hamstra, D.A.; Kievit, E.; Davis, M.A.; Ng, E.Y.; Dornfeld, K.; Lawrence, T.S.
Extracellular expression of cytosine deaminase results in increased 5-FU production for enhanced enzyme/prodrug therapy (2004), Anticancer Res., 24, 1393-1399.

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Application

Application	Comment	Organism
medicine	construction of secreted form of enzyme by fusion with pre-prosegment of human tissue plasminogen activator. Secreted enzyme temporarily spares transduced cells and enhanced accumulation of extracellular 5-fluorouracil. Tumors expressing the secreted enzyme have an improved response to 5-fluorocytosine treatment compared to tumors expressing intracellular enzyme	Escherichia coli

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of secreted form of enzyme by fusion with pre-prosegment of human tissue plasminogen activator. Secreted enzyme temporarily spares transduced cells and enhanced accumulation of extracellular 5-fluorouracil. Tumors expressing the secreted enzyme have an improved response to 5-fluorocytosine treatment compared to tumors expressing intracellular enzyme	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

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Release 2023.1 (January 2023)