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Literature summary for 3.5.3.6 extracted from

  • Lu, X.; Li, L.; Feng, X.; Wu, Y.; Dunaway-Mariano, D.; Engen, J.R.; Mariano, P.S.
    L-Canavanine is a time-controlled mechanism-based inhibitor of Pseudomonas aeruginosa arginine deiminase (2005), J. Am. Chem. Soc., 127, 16412-16413.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
L-canavanine a time-controlled, competitive, mechanism-based inhibitor, the close structural similarity between L-arginine and L-canavanine suggests that an analogous pathway is responsible for the inactivation-reactivation cycle; slow substrate inhibitor that functions by covalent modification of the active-site Cys406 residue in the form of a thiouranoim salt Pseudomonas aeruginosa

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine + H2O Pseudomonas aeruginosa
-
L-citrulline + NH3
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Arg + H2O
-
Pseudomonas aeruginosa citrulline + NH3
-
?
L-arginine + H2O
-
Pseudomonas aeruginosa L-citrulline + NH3
-
?
L-arginine + H2O via enzyme Cys-bound S-alkyl-thiouronium intermediate, residues Asp166 and Asp280 are involved, overview Pseudomonas aeruginosa L-citrulline + NH3
-
?
L-canavanine + H2O via enzyme Cys-bound S-alkyl-thiouronium intermediate, residues Asp166 and Asp280 are involved, overview Pseudomonas aeruginosa O-ureidohomoserine + NH3 product identification by mass spectrometry ?

Synonyms

Synonyms Comment Organism
ADI
-
Pseudomonas aeruginosa
More the enzyme belongs to the L-arginine metabolizing, guanidino-transferring enzyme superfamily Pseudomonas aeruginosa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Pseudomonas aeruginosa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.6
-
assay at Pseudomonas aeruginosa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.7
-
L-canavanine
-
Pseudomonas aeruginosa