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Literature summary for 3.5.3.18 extracted from

  • Chertow, J.H.; Alkaitis, M.S.; Nardone, G.; Ikeda, A.K.; Cunnington, A.J.; Okebe, J.; Ebonyi, A.O.; Njie, M.; Correa, S.; Jayasooriya, S.; Casals-Pascual, C.; Billker, O.; Conway, D.J.; Walther, M.; Ackerman, H.
    Plasmodium infection is associated with impaired hepatic dimethylarginine dimethylaminohydrolase activity and disruption of nitric oxide synthase inhibitor/substrate homeostasis (2015), PLoS Pathog., 11, e1005119 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine in a mouse model of severe malaria, Plasmodium berghei ANKA infection inactivates hepatic DDAH1 via a post-transcriptional mechanism as evidenced by stable mRNA transcript number, decreased DDAH1 protein concentration, decreased enzyme activity, elevated tissue asymmetric dimethylarginine, elevated asymmetric dimethylarginine/arginine ratio in plasma, and decreased whole blood nitrite concentration Mus musculus
medicine plasma asymmetric dimethylarginine/arginine ratios are elevated in children with acute severe malaria compared to 28-day follow-up values and compared to children with uncomplicated malaria or healthy children Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O94760 isoform Ddah1
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Mus musculus Q9CWS0 isoform Ddah1
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Source Tissue

Source Tissue Comment Organism Textmining