Literature summary for 3.5.3.18 extracted from

Lambden, S.; Kelly, P.; Ahmetaj-Shala, B.; Wang, Z.; Lee, B.; Nandi, M.; Torondel, B.; Delahaye, M.; Dowsett, L.; Piper, S.; Tomlinson, J.; Caplin, B.; Colman, L.; Boruc, O.; Slaviero, A.; Zhao, L.; Oliver, E.; Khadayate, S.; Singer, M.; Arrigoni, F.; Leiper, J.
Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in polymicrobial sepsis (2015), Arterioscler. Thromb. Vasc. Biol., 35, 1382-1392 .

Application

Application	Comment	Organism
medicine	global knockout of Ddah2 results in elevated blood pressure during periods of activity and changes in vascular responsiveness mediated by changes in methylarginine concentration, and systemic nitric oxide concentrations. In a model of severe polymicrobial sepsis, Ddah2 knockout affects outcome. Monocyte-specific deletion of Ddah2 results in a similar pattern of increased severity to that seen in globally deficient animals	Mus musculus

Organism	UniProt	Comment	Textmining
Mus musculus	Q99LD8	isoform Ddah2	-

General Information	Comment	Organism
physiological function	global knockout of Ddah2 results in elevated blood pressure during periods of activity and changes in vascular responsiveness mediated by changes in methylarginine concentration, and systemic nitric oxide concentrations. In a model of severe polymicrobial sepsis, Ddah2 knockout affects outcome. Monocyte-specific deletion of Ddah2 results in a similar pattern of increased severity to that seen in globally deficient animals	Mus musculus

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Release 2023.1 (January 2023)