Inhibitors | Comment | Organism | Structure |
---|---|---|---|
homocysteine | inhibition of the expression of DDAH-2 reduces the NO production induced by IL-1beta | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | conventional immunofluorescence and confocal microscopy reveal the presence of DDAH-2 in the mitochondria of IL-1beta-stimulated chondrocytes. Blocking the translocation to mitochondria reduces the NO production induced by IL-1beta | Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cartilage | DDAH-2 protein expression is higher in osteoarthritic cartilage than in normal cartilage | Homo sapiens | - |
chondrocyte | - |
Homo sapiens | - |
knee | normal human chondrocytes are isolated from knee cartilage obtained | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
DDAH-2 | - |
Homo sapiens |
dimethylarginine dimethylaminohydrolase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | DDAH-2 protein expression is higher in osteoarthritic cartilage than in normal cartilage | up |
Homo sapiens | in chondrocyte mitochondria extracts, DDAH-2 expression is significantly increased after exposure to IL-1beta | up |