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Literature summary for 3.5.3.18 extracted from

  • Hu, X.; Atzler, D.; Xu, X.; Zhang, P.; Guo, H.; Lu, Z.; Fassett, J.; Schwedhelm, E.; Boeger, R.H.; Bache, R.J.; Chen, Y.
    Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine (2011), Arterioscler. Thromb. Vasc. Biol., 31, 1540-1546.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Synonyms

Synonyms Comment Organism
DDAH1
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 Mus musculus
dimethylarginine dimethylaminohydrolase
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 Mus musculus

General Information

General Information Comment Organism
malfunction plasma and tissue asymmetrical dimethylarginine (ADMA) and N-monomethyl-L-arginine (L-NMMA) levels in DDAH1-/- mice are several folds higher than in wild-type mice, but growth and development of these knockout mice are similar to wild-type. Although the expression of DDAH2 is unaffected, DDAH activity is undetectable in all tissues tested. Results indicate that DDAH1 is the critical enzyme for ADMA and L-NMMA degradation Mus musculus