Literature summary for 3.5.3.18 extracted from

Rodionov, R.N.; Dayoub, H.; Lynch, C.M.; Wilson, K.M.; Stevens, J.W.; Murry, D.J.; Kimoto, M.; Arning, E.; Bottiglieri, T.; Cooke, J.P.; Baumbach, G.L.; Faraci, F.M.; Lentz, S.R.
Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia (2010), Circ. Res., 106, 551-558.

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Application

Application	Comment	Organism
medicine	hyperhomocysteinemia is induced in human DDAH1 transgenic mice and wild-type littermates using a high methionine/low folate diet. Plasma total homocysteine is elevated approximately 3fold in both wild-type and DDAH1 transgenic mice fed the high methionine/low folate diet compared with the control diet. Plasma asymmetrical dimethylarginine is approximately 40% lower in DDAH1 transgenic mice compared with wild-type mice irrespective of diet. Responses to 10 microM papaverine, a direct smooth muscle dilator, are impaired with the high methionine/low folate diet in wild-type mice but not DDAH1 transgenic mice. DDAH1 transgenic mice also are protected from hypertrophy of cerebral arterioles but not from accelerated carotid artery thrombosis induced by the high methionine/low folate diet	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

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Release 2023.1 (January 2023)