Activating Compound | Comment | Organism | Structure |
---|---|---|---|
adiponectin | - |
Homo sapiens | |
all-trans-retinoic acid | 1.9fold increase in DDAH-2 mRNA and protein expression | Mus musculus | |
aminoguanidine | - |
Rattus norvegicus | |
aspirin | - |
Rattus norvegicus | |
EDTA | - |
Rattus norvegicus | |
epigallocatechin gallate | - |
Homo sapiens | |
fenofibrate | - |
Homo sapiens | |
Insulin | - |
Homo sapiens | |
interleukin-1beta | - |
Rattus norvegicus | |
interleukin-1beta | 2fold increase in DDAH-1 protein expression | Rattus norvegicus | |
losartan | - |
Homo sapiens | |
nebivolol | 2fold increase in DDAH-2 mRNA and protein expression | Homo sapiens | |
oestradiol | 60-70% increase in DDAH-2 mRNA and protein expression | Homo sapiens | |
pioglitazone | 2-3fold increase of DDAH-2 mRNA and protein levels | Rattus norvegicus | |
pravastatin | - |
Rattus norvegicus | |
probucol | - |
Homo sapiens | |
taurin | - |
Bos taurus | |
taurin | - |
Rattus norvegicus | |
taurin | - |
Homo sapiens | |
taurine | - |
Oryctolagus cuniculus | |
taurine | - |
Mus musculus | |
telmisartan | - |
Bos taurus | |
telmisartan | - |
Oryctolagus cuniculus | |
telmisartan | - |
Rattus norvegicus | |
telmisartan | - |
Mus musculus | |
telmisartan | - |
Homo sapiens | |
vitamin E | - |
Bos taurus | |
vitamin E | - |
Oryctolagus cuniculus | |
vitamin E | - |
Rattus norvegicus | |
vitamin E | - |
Mus musculus | |
vitamin E | - |
Homo sapiens | |
xanthone | - |
Bos taurus | |
xanthone | - |
Oryctolagus cuniculus | |
xanthone | - |
Rattus norvegicus | |
xanthone | - |
Mus musculus | |
xanthone | - |
Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | influence on atherosclerosis in experimental models by increased ADMA concentrations and reduced NO synthesis | Bos taurus |
medicine | influence on atherosclerosis in experimental models by increased ADMA concentrations and reduced NO synthesis | Oryctolagus cuniculus |
medicine | influence on atherosclerosis in experimental models by increased ADMA concentrations and reduced NO synthesis | Rattus norvegicus |
medicine | influence on atherosclerosis in experimental models by increased ADMA concentrations and reduced NO synthesis | Mus musculus |
medicine | influence on atherosclerosis in experimental models by increased ADMA concentrations and reduced NO synthesis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(N,N-dimethylamino)diazenolate-2-oxide | 1 mM, 50% inhibition of DDAH-1 | Homo sapiens | |
2-(N,N-dimethylamino)diazenolate-2-oxide | 1 mM, 50% inhibition of DDAH-1; 1 mM, 50% inhibition of DDAH-1 | Mus musculus | |
2-(N,N-dimethylamino)diazenolate-2-oxide | 1 mM, 50% inhibition of DDAH-1 | Rattus norvegicus | |
4-hydroxy-2-nonenal | 50 microM, 50% relative activity | Homo sapiens | |
angiotensin II | 1 microM, about 55% relative activity; 1 microM, about 55% relative activity | Homo sapiens | |
cytokine induced nitric-oxide synthesis | - |
Homo sapiens | |
erythropoetin | 200 units/ml, about 75% relative activity; 200 units/ml, about 75% relative activity | Homo sapiens | |
glucose | - |
Homo sapiens | |
glucose | 25.5 mmol/l; 25.5 mmol/l | Mus musculus | |
glucose | 25.5 mmol/l; 25.5 mmol/l | Rattus norvegicus | |
glycosylated bovine serum albumin | - |
Rattus norvegicus | |
homocysteine | - |
Homo sapiens | |
hydrogen peroxide | 100 microM, 50% relative activity | Homo sapiens | |
lipopolysaccharide | 1 microg/ml, 24 h, about 55% relative activity; 1 microg/ml, about 55% relative activity | Homo sapiens | |
low-density-lipoprotein | 100 microg/ml | Homo sapiens | |
lysophosphatidylcholine | 10 microg/ml, about 35% relative activity | Homo sapiens | |
Mercuric chloride | - |
Rattus norvegicus | |
N-(2-methoxyethyl)-L-arginine | complete inhibition at 100 microM; complete inhibition at 100 microM | Rattus norvegicus | |
N-(2-methoxyethyl)arginine | - |
Mus musculus | |
N-(2-methoxyethyl)arginine methyl esther | - |
Mus musculus | |
N-nitro-L-arginine methylester | 1 mM, 1 h, 47.1% relative activity; 1mM, 1 h, 47.1% relative activity | Bos taurus | |
N-nitro-L-arginine methylester | 1mM, 1 h, 47.1% relative activity | Homo sapiens | |
N-nitro-L-arginine methylester | - |
Mus musculus | |
N-nitro-L-arginine methylester | 1 mM, 1 h, 47.1% relative activity | Oryctolagus cuniculus | |
N-nitro-L-arginine methylester | - |
Rattus norvegicus | |
Nicotine | 50% decrease in DDAH-2 mRNA | Homo sapiens | |
nitric oxide | increased NO production nitrosates DDAH | Homo sapiens | |
nitroglycerine | 10 microM, 16 h, about 55% relative activity; 10 microM, about 55% relative activity | Homo sapiens | |
peroxynitrite | - |
Homo sapiens | |
S-2-amino-4-[N-(2-methoxyethyl)guanidino]butanoic acid benzyl ester | - |
Rattus norvegicus | |
TNF-alpha | 250 U/ml, 63% relative activity | Homo sapiens | |
Zn2+ | 20 microM, 40% relative activity; 20 microM, 40% relative activity | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.18 | - |
dimethyl-L-arginine | - |
Bos taurus | |
0.18 | - |
dimethyl-L-arginine | - |
Oryctolagus cuniculus | |
0.18 | - |
dimethyl-L-arginine | - |
Rattus norvegicus | |
0.18 | - |
dimethyl-L-arginine | - |
Mus musculus | |
0.18 | - |
dimethyl-L-arginine | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Bos taurus | Q3SX44 | - |
- |
Homo sapiens | O94760 | - |
- |
Homo sapiens | O95865 | - |
- |
Mus musculus | Q99LD8 | - |
- |
Mus musculus | Q9CWS0 | - |
- |
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | O08557 | - |
- |
Rattus norvegicus | Q6MG60 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aortic endothelial cell | - |
Rattus norvegicus | - |
brain | - |
Bos taurus | - |
ECV304 cell | - |
Homo sapiens | - |
endothelial cell | sEnd-1 cells | Mus musculus | - |
heart | - |
Oryctolagus cuniculus | - |
heart | - |
Rattus norvegicus | - |
heart | - |
Mus musculus | - |
heart | - |
Homo sapiens | - |
heart | - |
Bos taurus | - |
HUVEC cell | - |
Homo sapiens | - |
kidney | - |
Bos taurus | - |
kidney | - |
Oryctolagus cuniculus | - |
kidney | - |
Rattus norvegicus | - |
kidney | - |
Mus musculus | - |
kidney | - |
Homo sapiens | - |
liver | - |
Bos taurus | - |
liver | - |
Oryctolagus cuniculus | - |
liver | - |
Mus musculus | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Homo sapiens | - |
placenta | - |
Oryctolagus cuniculus | - |
placenta | - |
Rattus norvegicus | - |
placenta | - |
Mus musculus | - |
placenta | - |
Homo sapiens | - |
placenta | - |
Bos taurus | - |
pulmonary artery endothelial cell | - |
Mus musculus | - |
smooth muscle | - |
Rattus norvegicus | - |
umbilical vein endothelial cell | - |
Homo sapiens | - |
vascular endothelium | - |
Oryctolagus cuniculus | - |
vascular endothelium | - |
Rattus norvegicus | - |
vascular endothelium | - |
Mus musculus | - |
vascular endothelium | - |
Homo sapiens | - |
vascular endothelium | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dimethyl-L-arginine + H2O | - |
Bos taurus | L-citrulline + dimethylamine | - |
? | |
dimethyl-L-arginine + H2O | - |
Oryctolagus cuniculus | L-citrulline + dimethylamine | - |
? | |
dimethyl-L-arginine + H2O | - |
Rattus norvegicus | L-citrulline + dimethylamine | - |
? | |
dimethyl-L-arginine + H2O | - |
Mus musculus | L-citrulline + dimethylamine | - |
? | |
dimethyl-L-arginine + H2O | - |
Homo sapiens | L-citrulline + dimethylamine | - |
? | |
Ngamma-monomethyl-L-arginine + H2O | - |
Bos taurus | L-citrulline + methylamine | - |
? | |
Ngamma-monomethyl-L-arginine + H2O | - |
Oryctolagus cuniculus | L-citrulline + methylamine | - |
? | |
Ngamma-monomethyl-L-arginine + H2O | - |
Rattus norvegicus | L-citrulline + methylamine | - |
? | |
Ngamma-monomethyl-L-arginine + H2O | - |
Mus musculus | L-citrulline + methylamine | - |
? | |
Ngamma-monomethyl-L-arginine + H2O | - |
Homo sapiens | L-citrulline + methylamine | - |
? | |
S-methyl-L-thiocitrulline + H2O | - |
Bos taurus | L-citrulline + methanethiol | - |
? | |
S-methyl-L-thiocitrulline + H2O | - |
Oryctolagus cuniculus | L-citrulline + methanethiol | - |
? | |
S-methyl-L-thiocitrulline + H2O | - |
Rattus norvegicus | L-citrulline + methanethiol | - |
? | |
S-methyl-L-thiocitrulline + H2O | - |
Mus musculus | L-citrulline + methanethiol | - |
? | |
S-methyl-L-thiocitrulline + H2O | - |
Homo sapiens | L-citrulline + methanethiol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DDAH-1 | - |
Bos taurus |
DDAH-1 | - |
Oryctolagus cuniculus |
DDAH-1 | - |
Mus musculus |
DDAH-1 | - |
Rattus norvegicus |
DDAH-1 | - |
Homo sapiens |
DDAH-2 | - |
Oryctolagus cuniculus |
DDAH-2 | - |
Rattus norvegicus |
DDAH-2 | - |
Mus musculus |
DDAH-2 | - |
Homo sapiens |
DDAH-2 | - |
Bos taurus |
dimethylarginine dimethylaminohydrolase | - |
Bos taurus |
dimethylarginine dimethylaminohydrolase | - |
Oryctolagus cuniculus |
dimethylarginine dimethylaminohydrolase | - |
Rattus norvegicus |
dimethylarginine dimethylaminohydrolase | - |
Mus musculus |
dimethylarginine dimethylaminohydrolase | - |
Homo sapiens |