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Literature summary for 3.5.3.18 extracted from

  • Leiper, J.; Murray-Rust, J.; McDonald, N.; Vallance, P.
    S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase (2002), Proc. Natl. Acad. Sci. USA, 99, 13527-13532.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.3.18

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Pseudomonas aeruginosa
expression in sEnd.1 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
C249S C249 is predominant target for S-nitrosylation Pseudomonas aeruginosa

Inhibitors

Inhibitors Comment Organism Structure
2-(N,N-dimethylamino)-diazenolate-2-oxide i.e. DEANONOate, inhibition by S-nitrosylation, reversed by dithiothreitol Homo sapiens
2-(N,N-dimethylamino)-diazenolate-2-oxide i.e. DEANONOate, inhibition by S-nitrosylation, reversed by dithiothreitol Pseudomonas aeruginosa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
 x * 40000, SDS-PAGE, His-tagged protein Pseudomonas aeruginosa
40000
-
 x * 40000, SDS-PAGE, Myc-tagged protein Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Pseudomonas aeruginosa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme, partial Homo sapiens
recombinant enzyme, partial Pseudomonas aeruginosa

Renatured (Commentary)

Renatured (Comment) Organism
inhibition by 2-(N,N-dimethylamino)-diazenolate-2-oxide is reversed by dithiothreitol Homo sapiens
inhibition by 2-(N,N-dimethylamino)-diazenolate-2-oxide is reversed by dithiothreitol Pseudomonas aeruginosa

Subunits

Subunits Comment Organism
? x * 40000, SDS-PAGE, His-tagged protein Pseudomonas aeruginosa
? x * 40000, SDS-PAGE, Myc-tagged protein Homo sapiens