Literature summary for 3.5.3.15 extracted from

Montgomery, A.B.; Kopec, J.; Shrestha, L.; Thezenas, M.L.; Burgess-Brown, N.A.; Fischer, R.; Yue, W.W.; Venables, P.J.
Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase implications for autoimmunity in rheumatoid arthritis (2016), Ann. Rheum. Dis., 75, 1255-1261 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Porphyromonas gingivalis

Crystallization (Commentary)

Crystallization (Comment)	Organism
structures of wild-type and mutant C351A, to 1.46 and 1.48 A resolution. Catalysis is mediated by residues Asp130, His236, Asp238, Asn297 and Cys351. Arg152 and Arg154 may determine the substrate specificity	Porphyromonas gingivalis

Protein Variants

Protein Variants	Comment	Organism
C351A	inactive	Porphyromonas gingivalis
R152A	significant reduction in activity	Porphyromonas gingivalis
R154A	activity is similar to wild-type	Porphyromonas gingivalis

Organism

Organism	UniProt	Comment	Textmining
Porphyromonas gingivalis	Q9RQJ2	-	-
Porphyromonas gingivalis W83	Q9RQJ2	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CESSSHHPGIAEFPS-R + H2O	i.e. fibrinogen peptide FibA-R	Porphyromonas gingivalis	CESSSHHPGIAEFPS-citrulline + NH3	-	?
CESSSHHPGIAEFPS-R + H2O	i.e. fibrinogen peptide FibA-R	Porphyromonas gingivalis W83	CESSSHHPGIAEFPS-citrulline + NH3	-	?
Gly-L-Arg + H2O	-	Porphyromonas gingivalis	Gly-citrulline + NH3	-	?
Gly-L-Arg + H2O	-	Porphyromonas gingivalis W83	Gly-citrulline + NH3	-	?
additional information	no substrates: peptides Arg-Gly-Glu, Met-Arg-Phe, fibrinogen peptide CESSSHHPGIAEFPS-R-GK	Porphyromonas gingivalis	?	-	?
additional information	no substrates: peptides Arg-Gly-Glu, Met-Arg-Phe, fibrinogen peptide CESSSHHPGIAEFPS-R-GK	Porphyromonas gingivalis W83	?	-	?
N-alpha-benzoyl-L-arginine ethyl ester + H2O	-	Porphyromonas gingivalis	N-alpha-benzoyl-L-citrulline ethyl ester + NH3	-	?
N-alpha-benzoyl-L-arginine ethyl ester + H2O	-	Porphyromonas gingivalis W83	N-alpha-benzoyl-L-citrulline ethyl ester + NH3	-	?

Synonyms

Synonyms	Comment	Organism
PPAD	-	Porphyromonas gingivalis

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Release 2023.1 (January 2023)