Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-({(1S)-1-(2-tert-butyl-2H-tetrazol-5-yl)-4-[(2-chloroethanimidoyl)amino]butyl}carbamoyl)benzoic acid | - |
Homo sapiens | |
2-({(1S)-1-(2-tert-butyl-2H-tetrazol-5-yl)-4-[(2-fluoroethanimidoyl)amino]butyl}carbamoyl)benzoic acid | - |
Homo sapiens | |
2-{[(1S)-4-[(2-chloroethanimidoyl)amino]-1-(2H-tetrazol-5-yl)butyl]carbamoyl}benzoic acid | 15fold selectivity versus PAD2 and PAD3; 15fold selectivity versus PAD2 and PAD3; 15fold selectivity versus PAD2 and PAD3; 15fold selectivity versus PAD2 and PAD3 | Homo sapiens | |
2-{[(1S)-4-[(2-fluoroethanimidoyl)amino]-1-(2H-tetrazol-5-yl)butyl]carbamoyl}benzoic acid | exhibits 20 to 30fold selectivity over isoform PAD2 and PAD3 when compared to PAD1; exhibits 20 to 30fold selectivity over isoform PAD2 and PAD3 when compared to PAD1; exhibits 20 to 30fold selectivity over isoform PAD2 and PAD3 when compared to PAD1; exhibits 20 to 30fold selectivity over isoform PAD2 and PAD3 when compared to PAD1 | Homo sapiens | |
chloroamidine | - |
Homo sapiens | |
N-[(1S)-4-[(2-chloroethanimidoyl)amino]-1-(2H-tetrazol-5-yl)butyl]benzamide | - |
Homo sapiens | |
N-[(1S)-4-[(2-chloroethanimidoyl)amino]-1-(2H-tetrazol-5-yl)butyl][1,1'-biphenyl]-4-carboxamide | - |
Homo sapiens | |
N-[(1S)-4-[(2-fluoroethanimidoyl)amino]-1-(2H-tetrazol-5-yl)butyl]benzamide | - |
Homo sapiens | |
N-[(1S)-4-[(2-fluoroethanimidoyl)amino]-1-(2H-tetrazol-5-yl)butyl][1,1'-biphenyl]-4-carboxamide | - |
Homo sapiens | |
N-{(1S)-1-(2-tert-butyl-2H-tetrazol-5-yl)-4-[(2-chloroethanimidoyl)amino]butyl}benzamide | - |
Homo sapiens | |
N-{(1S)-1-(2-tert-butyl-2H-tetrazol-5-yl)-4-[(2-chloroethanimidoyl)amino]butyl}[1,1'-biphenyl]-4-carboxamide | - |
Homo sapiens | |
N-{(1S)-1-(2-tert-butyl-2H-tetrazol-5-yl)-4-[(2-fluoroethanimidoyl)amino]butyl}benzamide | highly selective isoform PAD2 inhibitor; highly selective isoform PAD2 inhibitor; highly selective isoform PAD2 inhibitor; highly selective isoform PAD2 inhibitor | Homo sapiens | |
N-{(1S)-1-(2-tert-butyl-2H-tetrazol-5-yl)-4-[(2-fluoroethanimidoyl)amino]butyl}[1,1'-biphenyl]-4-carboxamide | preferentially inhibits isoform PAD2 by 3 to 25fold with the highest selectivity being observed for PAD2 over PAD4; preferentially inhibits isoform PAD2 by 3 to 25fold with the highest selectivity being observed for PAD2 over PAD4; preferentially inhibits isoform PAD2 by 3 to 25fold with the highest selectivity being observed for PAD2 over PAD4; preferentially inhibits isoform PAD2 by 3 to 25fold with the highest selectivity being observed for PAD2 over PAD4 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
protein L-arginine + H2O | Homo sapiens | - |
protein L-citrulline + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9ULC6 | - |
- |
Homo sapiens | Q9ULW8 | - |
- |
Homo sapiens | Q9UM07 | - |
- |
Homo sapiens | Q9Y2J8 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
protein L-arginine + H2O | - |
Homo sapiens | protein L-citrulline + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAD1 | isoform | Homo sapiens |
PAD2 | isoform | Homo sapiens |
PAD3 | isoform | Homo sapiens |
PAD4 | isoform | Homo sapiens |