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Literature summary for 3.5.3.15 extracted from

  • Mohlake, P.; Whiteley, C.G.
    Arginine metabolising enzymes as therapeutic tools for Alzheimers disease: peptidyl arginine deiminase catalyses fibrillogenesis of beta-amyloid peptides (2010), Mol. Neurobiol., 41, 149-158.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.35
-
Nalpha-benzoyl-L-arginine ethyl ester pH 7.5, 68°C Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
PAD is purified in 12.5% yield and 137fold from bovine brain by chromatography on diethylaminoethyl (DEAE)-sephacel Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
59
-
pH 7.5, 68°C Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PAD II not only binds with the beta-amyloid peptides Abeta1-40, Abeta22-35, Abeta17-28,Abeta25-35 and Abeta32-35 but assists in the proteolytic degradation of these peptides with the concomitant formation of insoluble fibrils Bos taurus ?
-
?
Nalpha-benzoyl-L-arginine ethyl ester + H2O
-
Bos taurus Nalpha-benzoyl-L-citrulline ethyl ester + NH3
-
?

Synonyms

Synonyms Comment Organism
PAD II
-
Bos taurus
peptidylarginine deiminase
-
Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
68
-
-
Bos taurus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
68
-
enzyme loses 50% of its activity within 38 min Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
Bos taurus