Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
75000 | - |
SDS-PAGE | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
protein L-Arg + H2O | Mus musculus | - |
protein L-citrulline + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
cerebellum | in Purkinje cells of the cerebellum | Mus musculus | - |
cerebral cortex | in neuronal cells of the cerebral cortex | Mus musculus | - |
hippocampus | - |
Mus musculus | - |
medulla oblongata | - |
Mus musculus | - |
midbrain | - |
Mus musculus | - |
olfactory bulb | - |
Mus musculus | - |
pons | - |
Mus musculus | - |
spinal cord | - |
Mus musculus | - |
thalamus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
protein L-Arg + H2O | - |
Mus musculus | protein L-citrulline + NH3 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 75000, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
PAD2 | - |
Mus musculus |
peptidylarginine deiminase 2 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | PAD2 mRNA expression is detected in the brains of mice as early as embryonic day 15, and its expression in cerebral cortex, hippocampus, and cerebellum increases significantly as the animals age from 3 to 30 months old, PAD2 mRNA levels in the cerebral cortex, cerebellum, and hippocampus at 30 months were about 1.6fold,1.5fold, and 1.6fold higher, respectively, than in 3-month-old animals | up |
General Information | Comment | Organism |
---|---|---|
physiological function | despite PAD2's normally inactive status, it becomes active and citrullinates cellular proteins, but only when the intracellular Ca2+ balance is upset during neurodegenerative changes. Abnormal protein citrullination by PAD2 is closely associated with the pathogenesis of neurodegenerative disorders such as Alzheimers disease and prion disease | Mus musculus |