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Literature summary for 3.5.3.15 extracted from

  • Ying, S.; Dong, S.; Kawada, A.; Kojima, T.; Chavanas, S.; Mechin, M.C.; Adoue, V.; Serre, G.; Simon, M.; Takahara, H.
    Transcriptional regulation of peptidylarginine deiminase expression in human keratinocytes (2009), J. Dermatol. Sci., 53, 2-9.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ Ca2+ is not only the indispensable factor in the environment of deimination reaction, but is also considered as a major regulator of PAD genes at the transcriptional level Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6TGC4
-
-
Homo sapiens Q9ULC6
-
-
Homo sapiens Q9ULW8
-
-
Homo sapiens Q9UM07
-
-
Homo sapiens Q9Y2J8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis isoform PAD2 is mainly detected in both the spinous and granular layers with a more intense staining of the latter Homo sapiens
-
epidermis isoform PAD3 expression is restricted to the granular layer and lower stratum corneum Homo sapiens
-
epidermis PAD1 is detected in the entire epidermis with an increasing intensity gradient from the basal to the granular layer Homo sapiens
-
hair follicle inner root sheath and cuticle of the hair follicles Homo sapiens
-
keratinocyte
-
Homo sapiens
-
medulla oblongata
-
Homo sapiens
-
medulla oblongata isoform PAD3 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
filaggrin L-Arg + H2O
-
Homo sapiens filaggrin citrulline + NH3
-
?
S100A3-L-arginine + H2O
-
Homo sapiens S100A3-L-citrulline + NH3
-
?

Synonyms

Synonyms Comment Organism
PAD1 isoform Homo sapiens
PAD2 isoform Homo sapiens
PAD3 isoform Homo sapiens
PAD4 isoform Homo sapiens
PAD6 isoform Homo sapiens
peptidylarginine deiminase
-
Homo sapiens