Literature summary for 3.5.3.15 extracted from

Hung, H.C.; Lin, C.Y.; Liao, Y.F.; Hsu, P.C.; Tsay, G.J.; Liu, G.Y.
The functional haplotype of peptidylarginine deiminase IV (S55G, A82V and A112G) associated with susceptibility to rheumatoid arthritis dominates apoptosis of acute T leukemia Jurkat cells (2007), Apoptosis, 12, 475-487.

Search for more literature for 3.5.3.15

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	ionomycin induces PADI4 expression	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
gene padi4, DNA and amino acid sequence determination and analysis of wild-type and mutant enzymes	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
A82V/A112G	naturally occuring single-nucleotide polymorphisms and site-directed mutagenesis, the SNP-PADI4 mutant haplotype shows a higher risk of rheumatoid arthritis due to correlation with the RA gene, because the mutant shows increased activity, compared to the wild-type PADI4, which promotes the autoimmune disease and apoptosis, overview	Homo sapiens
S55G/A112G	naturally occuring single-nucleotide polymorphisms and site-directed mutagenesis, the SNP-PADI4 mutant haplotype shows a higher risk of rheumatoid arthritis due to correlation with the RA gene, because the mutant shows increased activity, compared to the wild-type PADI4, which promotes the autoimmune disease and apoptosis, overview	Homo sapiens
S55G/A82V	naturally occuring single-nucleotide polymorphisms and site-directed mutagenesis, the SNP-PADI4 mutant haplotype shows reduced activity compared to the wild-type PADI4	Homo sapiens
S55G/A82V/A112G	naturally occuring single-nucleotide polymorphisms and site-directed mutagenesis, the SNP-PADI4 mutant haplotype shows a higher risk of rheumatoid arthritis due to correlation with the RA gene, because the mutant shows increased activity, compared to the wild-type PADI4, which promotes the autoimmune disease and apoptosis, overview	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	required	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
protein-L-arginine + H2O	Homo sapiens	posttranslational convertion, PADI4 plays an essential role in immune cell differentiation and apoptosis, ionomycin-inducible PADI4-decreased cell viability and PADI4-enhanced apoptosis, overview	protein-L-citrulline + NH3	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	gene padi4, isozyme PADI4	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
JURKAT cell	T-cell leukemia cell line with tetracycline resistance	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
protein-L-arginine + H2O	-	Homo sapiens	protein-L-citrulline + NH3	-	?
protein-L-arginine + H2O	posttranslational convertion, PADI4 plays an essential role in immune cell differentiation and apoptosis, ionomycin-inducible PADI4-decreased cell viability and PADI4-enhanced apoptosis, overview	Homo sapiens	protein-L-citrulline + NH3	-	?

Synonyms

Synonyms	Comment	Organism
PADI4	-	Homo sapiens
peptidylarginine deiminase IV	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)