Literature summary for 3.5.3.15 extracted from

Nachat, R.; Mechin, M.C.; Takahara, H.; Chavanas, S.; Charveron, M.; Serre, G.; Simon, M.
Peptidylarginine deiminase isoforms 1-3 are expressed in the epidermis and involved in the deimination of K1 and filaggrin (2005), J. Invest. Dermatol., 124, 384-393.

Search for more literature for 3.5.3.15

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9ULC6	-	-
Homo sapiens	Q9ULW8	-	-
Homo sapiens	Q9Y2J8	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
epidermis	expression of isoform PAD3 is restricted to granular layer and lower stratum corneum	Homo sapiens	-
epidermis	isoform PAD1 is detected in all layers of the epidermis, including the stratum corneum	Homo sapiens	-
keratinocyte	expression of isoform PAD2 in all layers of living keratinocytes with a gradient of expression increasing from the basal (very low detection) to the granular layer, where the protein is located at the cell periphery	Homo sapiens	-
stratum corneum	isoform PAD1	Homo sapiens	-
stratum corneum	isoform PAD3 is expressed in granular level of stratum corneum	Homo sapiens	-
stratum granulosum	expression of isoform PAD2	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
filaggrin L-arginine + H2O	isoform PAD1	Homo sapiens	filaggrin L-citrulline + NH3	-	?
filaggrin L-arginine + H2O	isoform PAD3	Homo sapiens	filaggrin L-citrulline + NH3	-	?

Synonyms

Synonyms	Comment	Organism
PAD1	-	Homo sapiens
PAD2	-	Homo sapiens
PAD3	-	Homo sapiens

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Release 2023.1 (January 2023)