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Literature summary for 3.5.3.15 extracted from
- Methylation of the guanidino group of arginine residues prevents citrullination by peptidylarginine deiminase IV (2005), FEBS Lett., 579, 4088-4092.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| benzoyl-Ngamma,Ngamma-dimethyl-Arg | IC50: 0.4 mM | Homo sapiens |  |
| benzoyl-Ngamma-methyl-Arg | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9UM07 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzoyl-Arg + H2O | - |
Homo sapiens | benzoyl-citrulline + NH3 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PAD IV | - |
Homo sapiens |
| peptidylarginine deiminase IV | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.4 | - |
IC50: 0.4 mM | Homo sapiens | benzoyl-Ngamma,Ngamma-dimethyl-Arg | |
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Release 2023.1 (January 2023)
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