KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.35 | - |
benzoyl-L-Arg ethyl ester | pH 7.6, 55°C, peptidylarginine deiminase 1 | Homo sapiens | |
0.38 | - |
benzoyl-L-Arg | pH 7.6, 55°C, peptidylarginine deiminase 1 | Homo sapiens | |
0.5 | - |
benzoyl-L-Arg ethyl ester | pH 7.6, 55°C, peptidylarginine deiminase 2 | Homo sapiens | |
0.91 | - |
acetyl-L-Arg | pH 7.6, 55°C, peptidylarginine deiminase 1 | Homo sapiens | |
1.19 | - |
acetyl-L-Arg methyl ester | pH 7.6, 55°C, peptidylarginine deiminase 1 | Homo sapiens | |
1.49 | - |
benzoyl-L-Arg | pH 7.6, 55°C, peptidylarginine deiminase 2 | Homo sapiens | |
3.73 | - |
acetyl-L-Arg methyl ester | pH 7.6, 55°C, peptidylarginine deiminase 2 | Homo sapiens | |
7.5 | - |
benzoyl-L-Arg ethyl ester | pH 7.6, 55°C, peptidylarginine deiminase 3 | Homo sapiens | |
33.6 | - |
benzoyl-L-Arg | pH 7.6, 55°C, peptidylarginine deiminase 3 | Homo sapiens | |
66.3 | - |
acetyl-L-Arg methyl ester | pH 7.6, 55°C, peptidylarginine deiminase 3 | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | 1 mM required for maximal deimination of filaggrin, peptidylarginine deiminase 1. Maximal deamination of benzoyl-L-Arg ethyl ester at 4 mM or above | Homo sapiens | |
Ca2+ | 1.5 mM required for maximal deimination of filaggrin, peptidylarginine deiminase 3, maximal deimination of benzoyl-L-Arg ethyl ester at 4 mM or above | Homo sapiens | |
Ca2+ | 2.5 mM required for maximal deamination of filaggrin, peptidylarginine deiminase 2. Maximal deimination of benzoyl-L-Arg ethyl ester at 4 mM or above | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
peptidylarginine deiminase 2 | - |
Homo sapiens | Q9ULC6 | peptidylarginine deiminase 1 | - |
Homo sapiens | Q9ULW8 | peptidylarginine deiminase 3 | - |
Purification (Comment) | Organism |
---|---|
recombinant peptidylarginine deiminase 1 | Homo sapiens |
recombinant peptidylarginine deiminase 2 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epidermis | peptidylarginine deiminase 1 | Homo sapiens | - |
epidermis | peptidylarginine deiminase 2 | Homo sapiens | - |
epidermis | peptidylarginine deiminase 3 | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.434 | - |
substrate: benzoyl-L-Arg ethyl ester, 55°C, peptidylarginine deiminase 2 | Homo sapiens |
0.583 | - |
substrate: benzoyl-L-Arg ethyl ester, 55°C, peptidylarginine deiminase 1 | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-L-Arg + H2O | peptidylarginine deiminase 1 | Homo sapiens | acetyl-L-citrulline + NH3 | - |
? | |
acetyl-L-Arg methyl ester + H2O | peptidylarginine deiminase 1 | Homo sapiens | acetyl-L-citrulline methyl ester + NH3 | - |
? | |
acetyl-L-Arg methyl ester + H2O | peptidylarginine deiminase 2 | Homo sapiens | acetyl-L-citrulline methyl ester + NH3 | - |
? | |
acetyl-L-Arg methyl ester + H2O | peptidylarginine deiminase 3 | Homo sapiens | acetyl-L-citrulline methyl ester + NH3 | - |
? | |
benzoyl-L-Arg + H2O | peptidylarginine deiminase 1 | Homo sapiens | benzoyl-L-citrulline + NH3 | - |
? | |
benzoyl-L-Arg + H2O | peptidylarginine deiminase 2 | Homo sapiens | benzoyl-L-citrulline + NH3 | - |
? | |
benzoyl-L-Arg + H2O | peptidylarginine deiminase 3 | Homo sapiens | benzoyl-L-citrulline + NH3 | - |
? | |
benzoyl-L-Arg ethyl ester + H2O | peptidylarginine deiminase 1 | Homo sapiens | benzoyl-L-citrulline ethyl ester + NH3 | - |
? | |
benzoyl-L-Arg ethyl ester + H2O | peptidylarginine deiminase 2 | Homo sapiens | benzoyl-L-citrulline ethyl ester + NH3 | - |
? | |
benzoyl-L-Arg ethyl ester + H2O | peptidylarginine deiminase 3 | Homo sapiens | benzoyl-L-citrulline ethyl ester + NH3 | - |
? | |
filaggrin L-arginine + H2O | peptidylarginine deiminase 1 | Homo sapiens | filaggrin L-citrulline + NH3 | - |
? | |
filaggrin L-arginine + H2O | peptidylarginine deiminase 2 | Homo sapiens | filaggrin L-citrulline + NH3 | - |
? | |
filaggrin L-arginine + H2O | peptidylarginine deiminase 3 | Homo sapiens | filaggrin L-citrulline + NH3 | - |
? | |
keratin L-arginine + H2O | peptidylarginine deiminase 1 | Homo sapiens | keratin L-citrulline + NH3 | - |
? | |
keratin L-arginine + H2O | peptidylarginine deiminase 2 | Homo sapiens | keratin L-citrulline + NH3 | - |
? | |
keratin L-arginine + H2O | peptidylarginine deiminase 3 | Homo sapiens | keratin L-citrulline + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAD1 | - |
Homo sapiens |
PAD2 | - |
Homo sapiens |
PAD3 | - |
Homo sapiens |
peptidylarginine deiminase 1 | - |
Homo sapiens |
peptidylarginine deiminase 2 | - |
Homo sapiens |
peptidylarginine deiminase 3 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.057 | 0.65 | benzoyl-L-Arg ethyl ester | pH 7.6, 55°C, peptidylarginine deiminase 1 | Homo sapiens | |
0.057 | 0.65 | acetyl-L-Arg methyl ester | pH 7.6, 55°C, peptidylarginine deiminase 1 | Homo sapiens | |
0.52 | - |
benzoyl-L-Arg | pH 7.6, 55°C, peptidylarginine deiminase 1 | Homo sapiens | |
0.55 | - |
benzoyl-L-Arg ethyl ester | pH 7.6, 55°C, peptidylarginine deiminase 2 | Homo sapiens | |
0.79 | - |
benzoyl-L-Arg | pH 7.6, 55°C, peptidylarginine deiminase 3 | Homo sapiens | |
1.73 | - |
benzoyl-L-Arg ethyl ester | pH 7.6, 55°C, peptidylarginine deiminase 3 | Homo sapiens | |
1.93 | - |
acetyl-L-Arg methyl ester | pH 7.6, 55°C, peptidylarginine deiminase 3 | Homo sapiens | |
3.15 | - |
benzoyl-L-Arg | pH 7.6, 55°C, peptidylarginine deiminase 2 | Homo sapiens | |
6.22 | - |
acetyl-L-Arg methyl ester | pH 7.6, 55°C, peptidylarginine deiminase 2 | Homo sapiens | |
11.28 | - |
acetyl-L-Arg methyl ester | pH 7.6, 55°C, peptidylarginine deiminase 1 | Homo sapiens | |
11.31 | - |
benzoyl-L-Arg ethyl ester | pH 7.6, 55°C, peptidylarginine deiminase 1 | Homo sapiens | |
13.68 | - |
acetyl-L-Arg | pH 7.6, 55°C, peptidylarginine deiminase 1 | Homo sapiens | |
14.43 | - |
benzoyl-L-Arg | pH 7.6, 55°C, peptidylarginine deiminase 1 | Homo sapiens | |
15.24 | - |
benzoyl-L-Arg ethyl ester | pH 7.6, 55°C, peptidylarginine deiminase 2 | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
deamination of fillagrin, peptidylarginine deiminase 3 | Homo sapiens |
8 | - |
deamination of fillagrin, peptidylarginine deiminase 1 | Homo sapiens |
8 | - |
deamination of fillagrin, peptidylarginine deiminase 2 | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5.2 | 8.9 | pH 5.2: about 60% of maximal activity, pH 8.9: about 85% of maximal activity, deamination of fillagrin, peptidylarginine deiminase 1 | Homo sapiens |
5.2 | 8.9 | pH 5.2: about 70% of maximal activity, pH 8.9: about 50% of maximal activity, deimination of fillagrin, peptidylarginine deiminase 3 | Homo sapiens |
5.2 | 8.9 | pH 5.2: about 70% of maximal activity, pH 8.9: about 75% of maximal activity, deimination of fillagrin, peptidylarginine deiminase 2 | Homo sapiens |