Literature summary for 3.5.3.15 extracted from

Vossenaar, E.R.; Radstake, T.R.; van der Heijden, A.; van Mansum, M.A.; Dieteren, C.; de Rooij, D.J.; Barrera, P.; Zendman, A.J.; van Venrooij, W.J.
Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages (2004), Ann. Rheum. Dis., 63, 373-381.

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	peptidylarginine deiminase 2 is activated only when sufficient Ca2+ is available (0.01 mM/l), at high concentrations that are normally not present in living cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y2J8	peptidylarginine deiminase 2, patients with rheumatoid arthitis and healthy controls	-
Homo sapiens	Q9Y2J8	peptidylarginine deiminase 4, patients with rheumatoid arthitis and healthy controls	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
macrophage	peptidylarginine deiminase 2, cell from patients with rheumatoid arthitis and healthy controls show identical expression patterns	Homo sapiens	-
monocyte	peptidylarginine deiminase 2, cell from patients with rheumatoid arthitis and healthy controls show identical expression patterns	Homo sapiens	-
monocyte	peptidylarginine deiminase 4, cell from patients with rheumatoid arthitis and healthy controls show identical expression patterns	Homo sapiens	-
additional information	no activity in macrophages	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
vimetin L-arginine + H2O	peptidylarginine deiminase 2	Homo sapiens	vimentin L-citrulline + NH3	-	?
vimetin L-arginine + H2O	peptidylarginine deiminase 4	Homo sapiens	vimentin L-citrulline + NH3	-	?

Synonyms

Synonyms	Comment	Organism
PAD2	-	Homo sapiens
PAD4	-	Homo sapiens
peptidylarginine deiminase 2	-	Homo sapiens
peptidylarginine deiminase 4	-	Homo sapiens

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Release 2023.1 (January 2023)