Literature summary for 3.5.3.15 extracted from

Zhang, J.; Dai, J.; Zhao, E.; Lin, Y.; Zeng, L.; Chen, J.; Zheng, H.; Wang, Y.; Li, X.; Ying, K.; Xie, Y.; Mao, Y.
cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type VI (2004), Acta Biochim. Pol., 51, 1051-1058.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	the enzyme catalyzes post-translational modification of protein through the conversion of arginine to citrulline in the presence of calcium ions. Peptidylarginine deiminase-mediated deimination of epithelial cell keratin resulting in cytoskeletal remodeling suggests a possible role for hPADVI in cytoskeletal reorganization in the egg and in early embryo development	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	fetal	Homo sapiens	-
leukocyte	in adult mainly expressed in ovary and peripheral blood leukocytes	Homo sapiens	-
liver	slight expression	Homo sapiens	-
lung	slight expression	Homo sapiens	-
ovary	in adult mainly expressed in ovary and peripheral blood leukocytes	Homo sapiens	-
spleen	slight expression	Homo sapiens	-
testis	slight expression	Homo sapiens	-
thymus	slight expression	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme catalyzes post-translational modification of protein through the conversion of arginine to citrulline in the presence of calcium ions. Peptidylarginine deiminase-mediated deimination of epithelial cell keratin resulting in cytoskeletal remodeling suggests a possible role for hPADVI in cytoskeletal reorganization in the egg and in early embryo development	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
hPADVI	-	Homo sapiens
peptidylarginine deiminase type VI	-	Homo sapiens

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Release 2023.1 (January 2023)