Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.3.1 extracted from

  • Golebiowski, A.; Paul Beckett, R.; Van Zandt, M.; Ji, M.K.; Whitehouse, D.; Ryder, T.R.; Jagdmann, E.; Andreoli, M.; Mazur, A.; Padmanilayam, M.; Cousido-Siah, A.; Mitschler, A.; Ruiz, F.X.; Podjarny, A.; Schroeter, H.
    2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors (2013), Bioorg. Med. Chem. Lett., 23, 2027-2030.
    View publication on PubMed
Search for more literature for 3.5.3.1

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with inhibitors, vapor diffusion method, using 100 mM malonic acid, imidazol, boric system pH 5, and 25% or 30% (w/v) polyethylene glycol 1500 for aginase I or II, respectively Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-(aminomethyl)-6-borononorleucine
-
 Homo sapiens
2-amino-6-borono-2-(difluoromethyl)-hexanoic acid
-
 Homo sapiens
2-amino-6-borono-2-butylhexanoic acid
-
 Homo sapiens
2-amino-6-borono-2-methyl-hexanoic acid
-
 Homo sapiens
2-amino-6-boronohexanoic acid
-
 Homo sapiens
2-[(benzylamino)methyl]-6-borononorleucine
-
 Homo sapiens
6-borono-2-(2-hydroxyethyl)norleucine
-
 Homo sapiens
6-borono-2-(3-methoxypropyl)norleucine
-
 Homo sapiens
6-borono-2-(hydroxymethyl)norleucine
-
 Homo sapiens
6-borono-2-ethylnorleucine
-
 Homo sapiens
6-borono-2-methylnorleucine
-
 Homo sapiens
6-borono-2-propan-2-ylnorleucine
-
 Homo sapiens
6-borono-2-[2-(4-hydroxypiperidin-1-yl)ethyl]norleucine
-
 Homo sapiens
6-borono-2-[2-(diethylamino)ethyl]norleucine
-
 Homo sapiens
6-borono-2-[2-(morpholin-4-yl)ethyl]norleucine
-
 Homo sapiens
6-borono-2-[2-(pyrrolidin-1-yl)ethyl]norleucine
-
 Homo sapiens
alpha-(4-boronobutyl)histidine
-
 Homo sapiens
alpha-(4-boronobutyl)phenylalanine
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ contains Mn2+ Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine + H2O Homo sapiens
-
 L-ornithine + urea
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P78540
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine + H2O
-
 Homo sapiens L-ornithine + urea
-
 ?

Synonyms

Synonyms Comment Organism
Arg II
-
 Homo sapiens
arginase II
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00032
-
 arginase I, at pH 7.4 and 37°C Homo sapiens 6-borono-2-[2-(pyrrolidin-1-yl)ethyl]norleucine
0.00037
-
 arginase I, at pH 7.4 and 37°C Homo sapiens 6-borono-2-[2-(4-hydroxypiperidin-1-yl)ethyl]norleucine
0.00052
-
 arginase I, at pH 7.4 and 37°C Homo sapiens 6-borono-2-[2-(diethylamino)ethyl]norleucine
0.00062
-
 arginase II, at pH 7.4 and 37°C Homo sapiens 6-borono-2-[2-(pyrrolidin-1-yl)ethyl]norleucine
0.000934
-
 arginase II, at pH 7.4 and 37°C Homo sapiens 6-borono-2-[2-(diethylamino)ethyl]norleucine
0.00098
-
 arginase II, at pH 7.4 and 37°C Homo sapiens 6-borono-2-[2-(4-hydroxypiperidin-1-yl)ethyl]norleucine
0.00135
-
 arginase II, at pH 7.4 and 37°C Homo sapiens 2-(aminomethyl)-6-borononorleucine
0.00145
-
 arginase I, at pH 7.4 and 37°C Homo sapiens 2-amino-6-boronohexanoic acid
0.00192
-
 arginase II, at pH 7.4 and 37°C Homo sapiens 2-amino-6-boronohexanoic acid
0.00207
-
 arginase I, at pH 7.4 and 37°C Homo sapiens 2-(aminomethyl)-6-borononorleucine
0.00225
-
 arginase I, at pH 7.4 and 37°C Homo sapiens 6-borono-2-(hydroxymethyl)norleucine
0.00228
-
 arginase I, at pH 7.4 and 37°C Homo sapiens alpha-(4-boronobutyl)histidine
0.00326
-
 arginase I, at pH 7.4 and 37°C Homo sapiens 2-[(benzylamino)methyl]-6-borononorleucine
0.0034
-
 arginase I, at pH 7.4 and 37°C Homo sapiens 6-borono-2-methylnorleucine
0.00372
-
 arginase II, at pH 7.4 and 37°C Homo sapiens alpha-(4-boronobutyl)histidine
0.00402
-
 arginase II, at pH 7.4 and 37°C Homo sapiens 6-borono-2-[2-(morpholin-4-yl)ethyl]norleucine
0.0041
-
 arginase I, at pH 7.4 and 37°C Homo sapiens 6-borono-2-ethylnorleucine
0.00428
-
 arginase II, at pH 7.4 and 37°C Homo sapiens 6-borono-2-(hydroxymethyl)norleucine
0.0045
-
 arginase II, at pH 7.4 and 37°C Homo sapiens 2-amino-6-borono-2-butylhexanoic acid
0.0046
-
 arginase II, at pH 7.4 and 37°C Homo sapiens 6-borono-2-ethylnorleucine
0.00512
-
 arginase I, at pH 7.4 and 37°C Homo sapiens 6-borono-2-(3-methoxypropyl)norleucine
0.00538
-
 arginase I, at pH 7.4 and 37°C Homo sapiens 6-borono-2-[2-(morpholin-4-yl)ethyl]norleucine
0.0057
-
 arginase II, at pH 7.4 and 37°C Homo sapiens 6-borono-2-methylnorleucine
0.00598
-
 arginase II, at pH 7.4 and 37°C Homo sapiens 2-[(benzylamino)methyl]-6-borononorleucine
0.00644
-
 arginase II, at pH 7.4 and 37°C Homo sapiens 6-borono-2-(3-methoxypropyl)norleucine
0.0105
-
 arginase I, at pH 7.4 and 37°C Homo sapiens alpha-(4-boronobutyl)phenylalanine
0.01124
-
 arginase I, at pH 7.4 and 37°C Homo sapiens 6-borono-2-propan-2-ylnorleucine
0.0155
-
 arginase II, at pH 7.4 and 37°C Homo sapiens 6-borono-2-propan-2-ylnorleucine
0.017
-
 arginase II, at pH 7.4 and 37°C Homo sapiens alpha-(4-boronobutyl)phenylalanine
0.019
-
 arginase I, at pH 7.4 and 37°C Homo sapiens 6-borono-2-(2-hydroxyethyl)norleucine
0.057
-
 arginase II, at pH 7.4 and 37°C Homo sapiens 6-borono-2-(2-hydroxyethyl)norleucine