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Literature summary for 3.5.3.1 extracted from

  • Yasuda, N.; Moriwaki, K.; Furuyama, S.
    Distribution and properties of arginase in the salivary glands of four species of laboratory mammals (2004), J. Comp. Physiol. B, 174, 237-242.
    View publication on PubMed
Search for more literature for 3.5.3.1

Inhibitors

Inhibitors Comment Organism Structure
L-ornithine
-
 Rattus norvegicus
Nomega-hydroxy-L-arginine
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-
particle-bound
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver highest enzymic activity Rattus norvegicus
-
salivary gland submandibular, sublingual, and parotid gland Mus musculus
-
salivary gland submandibular, sublingual, and parotid gland, 3.6-7.3% of the activity in liver. In submandibluar gland, presence of both isoform arginase I and arginase II Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
8.7
-
 pH 9.5, 37°C, enzyme from submandibular gland Mus musculus
20.3
-
 pH 9.5, 37°C, enzyme from parotid gland Mus musculus
20.3
-
 pH 9.5, 37°C, enzyme from parotid gland Rattus norvegicus
30.8
-
 pH 9.5, 37°C, enzyme from submandibular gland Rattus norvegicus
41.5
-
 pH 9.5, 37°C, enzyme from sublingual gland Mus musculus
41.5
-
 pH 9.5, 37°C, enzyme from sublingual gland Rattus norvegicus
562
-
 pH 9.5, 37°C, enzyme from liver Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine + H2O
-
 Mus musculus L-ornithine + urea
-
 ?
L-arginine + H2O
-
 Rattus norvegicus L-ornithine + urea
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.05
-
 Nomega-hydroxy-L-arginine pH 9.5, 37°C, liver enzyme Rattus norvegicus
0.061
-
 Nomega-hydroxy-L-arginine pH 9.5, 37°C, enzyme from submandibular gland Rattus norvegicus
1.4
-
 L-ornithine pH 9.5, 37°C, liver enzyme Rattus norvegicus
7.8
-
 L-ornithine pH 9.5, 37°C, enzyme from submandibular gland Rattus norvegicus