Literature summary for 3.5.3.1 extracted from

Colleluori, D.M.; Reczkowski, R.S.; Emig, F.A.; Cama, E.; Cox, J.D.; Scolnick, L.R.; Compher, K.; Jude, K.; Han, S.; Viola, R.E.; Christianson, D.W.; Ash, D.E.
Probing the role of the hyper-reactive histidine residue of arginase (2005), Arch. Biochem. Biophys., 444, 15-26.

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Protein Variants

Protein Variants	Comment	Organism
additional information	mutation of H141 to study its role in catalysis	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
diethyl dicarbonate	second-order rate constant of 113 per M and s for inactivation process. L-ornithine partially protects, L-ornithine plus borate completely protect	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
L-arginine + H2O = L-ornithine + urea	H141 serves as an acid/base catalyst, deprotonating the metal-bridging water molecule to generate the metal-bridging hydroxide nucleophile, and by protonating the amino group of the product to facilitate its departure	Rattus norvegicus	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

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Release 2023.1 (January 2023)