Application | Comment | Organism |
---|---|---|
medicine | potenial implications for carcinogenesis and cancer chemotherapy | Homo sapiens |
medicine | animal model for the human condition 5-oxoprolinuria, an inborn deficiency of renal 5-oxoprolinase activity | Homo sapiens |
medicine | animal model for the human condition 5-oxoprolinuria, an inborn deficiency of renal 5-oxoprolinase activity | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
cytoplasm | - |
Rattus norvegicus | 5737 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
140000 | - |
2 * 140000, SDS-PAGE | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-oxo-L-proline + H2O + ATP | Homo sapiens | - |
L-glutamate + ADP + phosphate | - |
? | |
5-oxo-L-proline + H2O + ATP | Rattus norvegicus | - |
L-glutamate + ADP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Rattus norvegicus | - |
rat | - |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | peripheral mononuclear cells | Homo sapiens | - |
kidney | - |
Homo sapiens | - |
kidney | - |
Rattus norvegicus | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
lung | - |
Homo sapiens | - |
lung | - |
Rattus norvegicus | - |
stomach | - |
Homo sapiens | - |
Storage Stability | Organism |
---|---|
-80°C, no activity lost for up to 1 week | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-oxo-L-proline + H2O + ATP | - |
Homo sapiens | L-glutamate + ADP + phosphate | - |
? | |
5-oxo-L-proline + H2O + ATP | - |
Rattus norvegicus | L-glutamate + ADP + phosphate | - |
? | |
L-2-oxothiazolidine-4-carboxylate + H2O + ATP | - |
Homo sapiens | L-cysteine + ADP + phosphate | - |
? | |
L-2-oxothiazolidine-4-carboxylate + H2O + ATP | - |
Rattus norvegicus | L-cysteine + ADP + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 140000, SDS-PAGE | Rattus norvegicus |