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Literature summary for 3.5.2.9 extracted from
- 5-Oxo-L-prolinase (L-pyroglutamate hydrolase). Studies of the chemical mechanism (1981), J. Biol. Chem., 256, 9981-9985.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-oxo-L-proline + H2O + ATP | Rattus norvegicus | conversion essentially irreversible, very slow reversal can be shown by measurement of ATP formation in presence of high glutamate concentrations | L-glutamate + ADP + phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
rat | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-imidazolidone-4-carboxylate + ATP + H2O | promotes enzymatic hydrolysis of ATP but is not itself hydrolyzed | Rattus norvegicus | 2-imidazolidone + ADP + phosphate | - |
? | |
| 2-piperidone-6-carboxylate + ATP + H2O | - |
Rattus norvegicus | 2-aminoadipate + phosphate + ADP | - |
? | |
| 5-oxo-L-proline + H2O + ATP | - |
Rattus norvegicus | L-glutamate + ADP + phosphate | - |
? | |
| 5-oxo-L-proline + H2O + ATP | conversion essentially irreversible, very slow reversal can be shown by measurement of ATP formation in presence of high glutamate concentrations | Rattus norvegicus | L-glutamate + ADP + phosphate | - |
? | |
| alpha-hydroxyglutarate lactone + H2O | - |
Rattus norvegicus | ? | - |
? | |
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