Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.2.3 extracted from

  • Kennedy, J.
    Dihydroorotase from rat liver: purification, properties and regulatory role in pyrimidine biosynthesis (1974), Arch. Biochem. Biophys., 160, 358-365.
    View publication on PubMed
Search for more literature for 3.5.2.3

Inhibitors

Inhibitors Comment Organism Structure
Ag2+ 0.2 mM, 63% inhibition Rattus norvegicus
Cd2+ 0.2 mM, 12% inhibition Rattus norvegicus
Cu2+ 0.2 mM, 33% inhibition Rattus norvegicus
Hg2+ 0.2 mM, 87% inhibition Rattus norvegicus
Zn2+ 0.2 mM, 18% inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.04
-
 L-dihydroorotate
-
 Rattus norvegicus
0.12
-
 L-carbamoylaspartate
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-carbamoyl-L-aspartate Rattus norvegicus
-
 L-dihydroorotate + H2O
-
 r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Storage Stability

Storage Stability Organism
-20°C, 1 month, 40% loss in activity Rattus norvegicus
4°C, 2 months, partially purified preparation Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-carbamoylaspartate
-
 Rattus norvegicus L-dihydroorotate + H2O
-
 r
N-carbamoyl-L-aspartate
-
 Rattus norvegicus L-dihydroorotate + H2O
-
 r