Literature summary for 3.5.2.2 extracted from

van Kuilenburg, A.B.; Meijer, J.; Dobritzsch, D.; Meinsma, R.; Duran, M.; Lohkamp, B.; Zoetekouw, L.; Abeling, N.G.; van Tinteren, H.L.; Bosch, A.M.
Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency (2007), Mol. Genet. Metab., 91, 157-164.

Search for more literature for 3.5.2.2

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
R412M	inactive enzyme, missense mutation causing dihydropyrimidase deficiency	Homo sapiens
W360R	inactive enzyme, missense mutation causing dihydropyrimidase deficiency	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5,6-dihydrothymine + H2O	-	Homo sapiens	N-carbamyl-beta-aminoisobutyrate	-	?
5,6-dihydrouracil + H2O	-	Homo sapiens	N-carbamyl-beta-alanine	-	?

Synonyms

Synonyms	Comment	Organism
DHP	-	Homo sapiens

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Release 2023.1 (January 2023)