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Literature summary for 3.5.2.2 extracted from
- The role of dihydropyrimidinase in the metabolism of some hydantoin and succinimide drugs (1974), Drug Metab. Dispos., 2, 103-112.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,6-dihydropyrimidine + H2O | Rattus norvegicus | - |
beta-ureido acid | - |
r |  |
| 5,6-dihydropyrimidine + H2O | Bos taurus | - |
beta-ureido acid | - |
r | |
| 5,6-dihydrothymine + H2O | Rattus norvegicus | - |
? | - |
? | |
| 5,6-dihydrothymine + H2O | Bos taurus | - |
? | - |
? | |
| 5,6-dihydrothymine + H2O | Rattus norvegicus Sprague-Dawley | - |
? | - |
? | |
| 5,6-dihydrouracil + H2O | Cavia porcellus | - |
3-ureidopropionate | - |
? | |
| 5,6-dihydrouracil + H2O | Mus musculus | - |
3-ureidopropionate | - |
? | |
| 5,6-dihydrouracil + H2O | Bos taurus | - |
3-ureidopropionate | - |
? | |
| 5,6-dihydrouracil + H2O | Oryctolagus cuniculus | - |
3-ureidopropionate | - |
? | |
| 5,6-dihydrouracil + H2O | Canis lupus familiaris | - |
3-ureidopropionate | - |
? | |
| hydantoin + H2O | Cavia porcellus | - |
N-carbamoyl glycine | - |
? | |
| hydantoin + H2O | Mus musculus | - |
N-carbamoyl glycine | - |
? | |
| hydantoin + H2O | Rattus norvegicus | - |
N-carbamoyl glycine | - |
? | |
| hydantoin + H2O | Bos taurus | - |
N-carbamoyl glycine | - |
? | |
| hydantoin + H2O | Oryctolagus cuniculus | - |
N-carbamoyl glycine | - |
? | |
| hydantoin + H2O | Canis lupus familiaris | - |
N-carbamoyl glycine | - |
? | |
| hydantoin + H2O | Felis catus | - |
N-carbamoyl glycine | - |
? | |
| hydantoin + H2O | Platyrrhini | - |
N-carbamoyl glycine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
ox | - |
| Bos taurus | - |
calf | - |
| Canis lupus familiaris | - |
dog | - |
| Cavia porcellus | - |
guinea-pig | - |
| Felis catus | - |
cat | - |
| Mus musculus | - |
mouse | - |
| Oryctolagus cuniculus | - |
rabbit | - |
| Platyrrhini | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Rattus norvegicus | - |
rat | - |
| Rattus norvegicus Sprague-Dawley | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Cavia porcellus | - |
| kidney | - |
Mus musculus | - |
| kidney | - |
Rattus norvegicus | - |
| kidney | - |
Bos taurus | - |
| kidney | - |
Oryctolagus cuniculus | - |
| kidney | - |
Canis lupus familiaris | - |
| kidney | - |
Felis catus | - |
| kidney | - |
Platyrrhini | - |
| liver | - |
Cavia porcellus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
| liver | - |
Oryctolagus cuniculus | - |
| liver | - |
Canis lupus familiaris | - |
| liver | - |
Platyrrhini | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, stable for protracted periods | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-methylhydantoin + H2O | - |
Rattus norvegicus | 3-methylhydantoic acid | - |
? | |
| 1-methylhydantoin + H2O | - |
Canis lupus familiaris | 3-methylhydantoic acid | - |
? | |
| 3-ethylphenylhydantoin + H2O | - |
Canis lupus familiaris | 2-phenylhydantoic acid | - |
? | |
| 3-methylphenylhydantoin + H2O | - |
Canis lupus familiaris | 2-phenylhydantoic acid | - |
? | |
| 3-phenylhydantoin + H2O | - |
Canis lupus familiaris | 2-phenylhydantoic acid | - |
? | |
| 5,6-dihydropyrimidine + H2O | - |
Rattus norvegicus | beta-ureido acid | - |
r | |
| 5,6-dihydropyrimidine + H2O | - |
Bos taurus | beta-ureido acid | - |
r | |
| 5,6-dihydrothymine + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 5,6-dihydrothymine + H2O | - |
Bos taurus | ? | - |
? | |
| 5,6-dihydrothymine + H2O | - |
Rattus norvegicus Sprague-Dawley | ? | - |
? | |
| 5,6-dihydrouracil + H2O | - |
Cavia porcellus | 3-ureidopropionate | - |
? | |
| 5,6-dihydrouracil + H2O | - |
Mus musculus | 3-ureidopropionate | - |
? | |
| 5,6-dihydrouracil + H2O | - |
Rattus norvegicus | 3-ureidopropionate | - |
? | |
| 5,6-dihydrouracil + H2O | - |
Bos taurus | 3-ureidopropionate | - |
? | |
| 5,6-dihydrouracil + H2O | - |
Oryctolagus cuniculus | 3-ureidopropionate | - |
? | |
| 5,6-dihydrouracil + H2O | - |
Canis lupus familiaris | 3-ureidopropionate | - |
? | |
| 5,6-dihydrouracil + H2O | - |
Felis catus | 3-ureidopropionate | - |
? | |
| 5,6-dihydrouracil + H2O | - |
Platyrrhini | 3-ureidopropionate | - |
? | |
| 5,6-dihydrouracil + H2O | - |
Rattus norvegicus Sprague-Dawley | 3-ureidopropionate | - |
? | |
| alpha-phenylsuccinimide + H2O | - |
Rattus norvegicus | 2-phenylsuccinamic acid | - |
? | |
| alpha-phenylsuccinimide + H2O | - |
Canis lupus familiaris | 2-phenylsuccinamic acid | - |
? | |
| D-2-phenylhydantoic acid + H2O | reverse reaction stereospecific, only D-isomer acts as substrate | Rattus norvegicus | 5-phenylhydantoin | - |
r | |
| dihydropyrimidine + H2O | - |
Rattus norvegicus | N-carbamoyl amino acid | - |
r | |
| dihydropyrimidine + H2O | - |
Bos taurus | N-carbamoyl amino acid | - |
r | |
| dihydropyrimidine + H2O | - |
Rattus norvegicus Sprague-Dawley | N-carbamoyl amino acid | - |
r | |
| DL-5-phenylhydantoin + H2O | - |
Cavia porcellus | N-carbamoyl-D-phenylglycine | - |
? | |
| DL-5-phenylhydantoin + H2O | - |
Mus musculus | N-carbamoyl-D-phenylglycine | - |
? | |
| DL-5-phenylhydantoin + H2O | - |
Rattus norvegicus | N-carbamoyl-D-phenylglycine | - |
r | |
| DL-5-phenylhydantoin + H2O | - |
Bos taurus | N-carbamoyl-D-phenylglycine | - |
? | |
| DL-5-phenylhydantoin + H2O | - |
Oryctolagus cuniculus | N-carbamoyl-D-phenylglycine | - |
? | |
| DL-5-phenylhydantoin + H2O | - |
Canis lupus familiaris | N-carbamoyl-D-phenylglycine | - |
? | |
| DL-5-phenylhydantoin + H2O | - |
Rattus norvegicus Sprague-Dawley | N-carbamoyl-D-phenylglycine | - |
r | |
| hydantoin + H2O | - |
Cavia porcellus | N-carbamoyl glycine | - |
? | |
| hydantoin + H2O | - |
Mus musculus | N-carbamoyl glycine | - |
? | |
| hydantoin + H2O | - |
Rattus norvegicus | N-carbamoyl glycine | - |
? | |
| hydantoin + H2O | - |
Bos taurus | N-carbamoyl glycine | - |
? | |
| hydantoin + H2O | - |
Oryctolagus cuniculus | N-carbamoyl glycine | - |
? | |
| hydantoin + H2O | - |
Canis lupus familiaris | N-carbamoyl glycine | - |
? | |
| hydantoin + H2O | - |
Felis catus | N-carbamoyl glycine | - |
? | |
| hydantoin + H2O | - |
Platyrrhini | N-carbamoyl glycine | - |
? | |
| additional information | - |
Bos taurus | ? | - |
? | |
| additional information | diphenylhydantoin and 5,5-disubstituted hydantoins like 5-ethyl-5-phenylhydantoin, 5,5-diphenylhydantoin, D-3-methyl-5-phenylhydantoin, D-3-ethyl-5-phenylhydantoin, alpha-methyl-alpha-phenylsuccinimide, N-methyl-alpha-phenylsuccinimide and alpha-ethyl-alpha-phenylglutarimide are no substrates | Rattus norvegicus | ? | - |
? | |
| additional information | diphenylhydantoin and 5,5-disubstituted hydantoins like 5-ethyl-5-phenylhydantoin, 5,5-diphenylhydantoin, D-3-methyl-5-phenylhydantoin, D-3-ethyl-5-phenylhydantoin, alpha-methyl-alpha-phenylsuccinimide, N-methyl-alpha-phenylsuccinimide and alpha-ethyl-alpha-phenylglutarimide are no substrates | Rattus norvegicus Sprague-Dawley | ? | - |
? | |
| succinimide + H2O | - |
Rattus norvegicus | ? | - |
? | |
| succinimide + H2O | - |
Bos taurus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 4,5-dihydropyrimidine amidohydrolase | - |
Rattus norvegicus |
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