Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | slightly inhibitory with carbamoyl beta-alanine or carbamoyl beta-aminoisobutyric acid as substrates | Bos taurus | |
Sn2+ | - |
Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.1 | - |
Hydrothymine | - |
Bos taurus | |
117.5 | - |
hydrouracil | - |
Bos taurus | |
830 | - |
hydantoin | - |
Bos taurus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | marked acceleration of carbamyl beta-alanine formation from hydrouracil, only slightly stimulatory with hydrothymine as substrate, no effect with hydantoin as substrate | Bos taurus | |
Mn2+ | marked acceleration of carbamoyl beta-alanine formation from hydrouracil | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hydantoin + H2O | Rattus norvegicus | - |
N-carbamoyl glycine | - |
? | |
hydantoin + H2O | Bos taurus | - |
N-carbamoyl glycine | - |
ir | |
hydantoin + H2O | Columba sp. | - |
N-carbamoyl glycine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
calf | - |
Bos taurus | - |
beef | - |
Columba sp. | - |
pigeon | - |
Rattus norvegicus | - |
rat | - |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Rattus norvegicus | - |
kidney | - |
Bos taurus | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Bos taurus | - |
liver | - |
Columba sp. | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
66.2 | - |
- |
Bos taurus |
Storage Stability | Organism |
---|---|
-20°C, stable for several months | Bos taurus |
4°C, dialyzed against phosphate or veronal buffer, pH 6.9 and pH 8.6, without loss of activity | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,6-dihydrouracil + H2O | - |
Rattus norvegicus | 3-ureidopropionate | - |
? | |
5,6-dihydrouracil + H2O | - |
Bos taurus | 3-ureidopropionate | - |
? | |
5,6-dihydrouracil + H2O | - |
Columba sp. | 3-ureidopropionate | - |
? | |
carbamoyl beta-aminoisobutyric acid + H2O | - |
Rattus norvegicus | ? | - |
? | |
carbamoyl beta-aminoisobutyric acid + H2O | - |
Bos taurus | ? | - |
? | |
hydantoin + H2O | - |
Rattus norvegicus | N-carbamoyl glycine | - |
? | |
hydantoin + H2O | - |
Bos taurus | N-carbamoyl glycine | - |
ir | |
hydantoin + H2O | - |
Columba sp. | N-carbamoyl glycine | - |
? | |
hydrothymine | - |
Rattus norvegicus | carbamoyl beta-aminoisobutyric acid | - |
? | |
hydrouracil + H2O | - |
Rattus norvegicus | N-carbamoyl beta-alanine | - |
? | |
additional information | - |
Rattus norvegicus | ? | - |
? | |
additional information | inactive with carbamoyl beta-alanine amide, barbituric acid, imidazole 4,5-dicarboxylic acid, 5-(carboxymethylidine)hydantoin, orotic acid, 4,5-aminoimidazolecarboximide, urocanic acid and 5-(diphenyl)hydantoin | Bos taurus | ? | - |
? | |
N-carbamoyl beta-alanine + H2O | - |
Rattus norvegicus | 5,6-dihydrouracil | - |
r | |
N-carbamoyl beta-alanine + H2O | - |
Bos taurus | 5,6-dihydrouracil | - |
r |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
7 | - |
Hydrothymine | - |
Bos taurus | |
71.7 | - |
hydrouracil | - |
Bos taurus | |
450 | - |
hydantoin | - |
Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.2 | - |
borate buffer, hydantoin as substrate | Bos taurus |
8.5 | - |
hydantoin as substrate | Bos taurus |