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Literature summary for 3.5.2.2 extracted from
- Bovine liver dihydropyrimidine amidohydrolase: pH dependencies of inactivation by chelators and steady-state kinetic properties (1986), Arch. Biochem. Biophys., 248, 368-378.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Bos taurus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,6-dipicolinic acid | - |
Bos taurus |  |
| 8-Hydroxyquinoline-5-sulfonic acid | - |
Bos taurus | |
| L-dihydroorotic acid | competitive inhibition | Bos taurus | |
| o-phenanthroline | - |
Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Bos taurus | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | essential, metalloenzyme | Bos taurus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 226000 | - |
- |
Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,6-dihydropyrimidine + H2O | Bos taurus | - |
beta-ureido acid | - |
r | |
| 5,6-dihydrouracil + H2O | Bos taurus | - |
3-ureidopropionate | - |
r | |
| hydantoin + H2O | Bos taurus | - |
N-carbamoyl glycine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
bovine | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Bos taurus | - |
| liver | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,6-dihydropyrimidine + H2O | - |
Bos taurus | beta-ureido acid | - |
r | |
| 5,6-dihydrouracil + H2O | - |
Bos taurus | 3-ureidopropionate | - |
r | |
| 5-bromo-5,6-dihydrouracil + H2O | - |
Bos taurus | ? | - |
r | |
| hydantoin + H2O | - |
Bos taurus | N-carbamoyl glycine | - |
? | |
| additional information | L-dihydroorotic acid is no substrate | Bos taurus | ? | - |
? | |
| succinimide + H2O | - |
Bos taurus | ? | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | - |
Bos taurus |
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Release 2023.1 (January 2023)
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