Literature summary for 3.5.2.17 extracted from

Lee, Y.; Park, B.C.; Lee, d.o..H.; Bae, K.H.; Cho, S.; Lee, C.H.; Lee, J.S.; Myung, P.K.; Park, S.G.
Mouse transthyretin-related protein is a hydrolase which degrades 5-hydroxyisourate, the end product of the uricase reaction (2006), Mol. Cell, 22, 141-145.

Search for more literature for 3.5.2.17

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21-DE3 cells	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
H102N	10fold reduced activity	Mus musculus
H11N	mutant almost abolishes activity	Mus musculus
additional information	the deletion mutation DELTAYRGS greatly affects activity	Mus musculus
R51E	mutant almost abolishes activity	Mus musculus
R51K	mutant fails to affect activity	Mus musculus
S118A	mutation has no influence on activity	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9CRB3	-	-

Purification (Commentary)

Purification (Comment)	Organism
glutathione-Sepharose 4B column chromatography	Mus musculus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5-hydroxyisourate + H2O	-	Mus musculus	5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate	-	?

Synonyms

Synonyms	Comment	Organism
5-hydroxyisourate hydrolase	-	Mus musculus
HIU hydrolase	-	Mus musculus
HIUHase	-	Mus musculus
transthyretin-related protein	-	Mus musculus
TRP	-	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)