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Literature summary for 3.5.1.B15 extracted from

  • Zhang, J.L.; Zheng, Q.C.; Li, Z.Q.; Zhang, H.X.
    Molecular dynamics simulations suggest ligands binding to nicotinamidase/pyrazinamidase (2012), PLoS ONE, 7, e39546.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure (PDB ID 2WT9) analysis, and modeling of substrate binding and unbinding, overview Acinetobacter baumannii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nicotinamide + H2O Acinetobacter baumannii
-
nicotinate + NH3
-
?
pyrazinamide + H2O Acinetobacter baumannii
-
pyrazinoic acid + NH3
-
?

Organism

Organism UniProt Comment Textmining
Acinetobacter baumannii B0VA03 gene pncA
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotinamide + H2O
-
Acinetobacter baumannii nicotinate + NH3
-
?
nicotinamide + H2O binding structure involving residues A155, C159, and Ile154, and unbinding mechanism, modeling, overview Acinetobacter baumannii nicotinate + NH3
-
?
pyrazinamide + H2O
-
Acinetobacter baumannii pyrazinoic acid + NH3
-
?

Synonyms

Synonyms Comment Organism
More cf. EC 3.5.1.19 Acinetobacter baumannii
nicotinamidase/pyrazinamidase
-
Acinetobacter baumannii
PncA
-
Acinetobacter baumannii
pyrazinamidase
-
Acinetobacter baumannii
PZAse
-
Acinetobacter baumannii

General Information

General Information Comment Organism
additional information protein conformational changes after ligand dissociation, molecular dynamics simulation methods are performed to investigate the unbinding process of nicotinamide using the enzyme's crystal structure. PDB ID 2WT9 Acinetobacter baumannii