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Literature summary for 3.5.1.99 extracted from
- Aryl and heteroaryl N-[4-[4-(2,3-substituted-phenyl)piperazine-1-yl]alkyl]carbamates with improved physico-chemical properties as dual modulators of dopamine D3 receptor and fatty acid amide hydrolase (2016), MedChemComm, 7, 537-541 .
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,2,3,4-tetrahydronaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate | 59.6% inhibition at 0.01 mM | Homo sapiens |  |
| 1-benzothiophen-4-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate | - |
Homo sapiens | |
| 1H-benzimidazol-4-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate | - |
Homo sapiens | |
| 1H-indol-4-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate | - |
Homo sapiens | |
| 2,3-dihydro-1,4-benzodioxin-5-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate | - |
Homo sapiens | |
| 4-carbamoylnaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate | - |
Homo sapiens | |
| 4-fluoronaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate | - |
Homo sapiens | |
| 4-hydroxynaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate | - |
Homo sapiens | |
| 4-methoxynaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate | - |
Homo sapiens | |
| 4-[([4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamoyl)oxy]naphthalene-1-carboxylic acid | - |
Homo sapiens | |
| 5,6,7,8-tetrahydronaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate | - |
Homo sapiens | |
| naphthalen-1-yl (3-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]propyl)carbamate | - |
Homo sapiens | |
| naphthalen-1-yl (4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]butyl)carbamate | - |
Homo sapiens | |
| naphthalen-1-yl [3-[4-(2,3-dichlorophenyl)piperazin-1-yl]propyl]carbamate | - |
Homo sapiens | |
| naphthalen-1-yl [3-[4-(3-methoxyphenyl)piperazin-1-yl]propyl]carbamate | - |
Homo sapiens | |
| naphthalen-1-yl [3-[4-(3-methylphenyl)piperazin-1-yl]propyl]carbamate | - |
Homo sapiens | |
| naphthalen-1-yl [4-[4-(3-methoxyphenyl)piperazin-1-yl]butyl]carbamate | - |
Homo sapiens | |
| naphthalen-1-yl [4-[4-(3-methylphenyl)piperazin-1-yl]butyl]carbamate | - |
Homo sapiens | |
| phenyl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FAAH | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00000063 | - |
pH and temperature not specified in the publication | Homo sapiens | phenyl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate | |
| 0.0000033 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-carbamoylnaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate | |
| 0.0000034 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-[([4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamoyl)oxy]naphthalene-1-carboxylic acid | |
| 0.0000045 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-fluoronaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate | |
| 0.0000053 | - |
pH and temperature not specified in the publication | Homo sapiens | naphthalen-1-yl [3-[4-(3-methylphenyl)piperazin-1-yl]propyl]carbamate | |
| 0.0000062 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-hydroxynaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate | |
| 0.0000062 | - |
pH and temperature not specified in the publication | Homo sapiens | naphthalen-1-yl [3-[4-(2,3-dichlorophenyl)piperazin-1-yl]propyl]carbamate | |
| 0.0000064 | - |
pH and temperature not specified in the publication | Homo sapiens | naphthalen-1-yl [3-[4-(3-methoxyphenyl)piperazin-1-yl]propyl]carbamate | |
| 0.0000069 | - |
pH and temperature not specified in the publication | Homo sapiens | 1H-indol-4-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate | |
| 0.0000069 | - |
pH and temperature not specified in the publication | Homo sapiens | naphthalen-1-yl (3-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]propyl)carbamate | |
| 0.0000075 | - |
pH and temperature not specified in the publication | Homo sapiens | 1H-benzimidazol-4-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate | |
| 0.0000114 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-benzothiophen-4-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate | |
| 0.000013 | - |
pH and temperature not specified in the publication | Homo sapiens | naphthalen-1-yl [4-[4-(3-methylphenyl)piperazin-1-yl]butyl]carbamate | |
| 0.0000215 | - |
pH and temperature not specified in the publication | Homo sapiens | naphthalen-1-yl (4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]butyl)carbamate | |
| 0.0000306 | - |
pH and temperature not specified in the publication | Homo sapiens | 2,3-dihydro-1,4-benzodioxin-5-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate | |
| 0.0000486 | - |
pH and temperature not specified in the publication | Homo sapiens | naphthalen-1-yl [4-[4-(3-methoxyphenyl)piperazin-1-yl]butyl]carbamate | |
| 0.000229 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-methoxynaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate | |
| 0.000244 | - |
pH and temperature not specified in the publication | Homo sapiens | 5,6,7,8-tetrahydronaphthalen-1-yl [4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]carbamate | |
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