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Literature summary for 3.5.1.99 extracted from

  • Cipriano, M.; Bjoerklund, E.; Wilson, A.A.; Congiu, C.; Onnis, V.; Fowler, C.J.
    Inhibition of fatty acid amide hydrolase and cyclooxygenase by the N-(3-methylpyridin-2-yl)amide derivatives of flurbiprofen and naproxen (2013), Eur. J. Pharmacol., 720, 383-390.
    View publication on PubMed
Search for more literature for 3.5.1.99

Inhibitors

Inhibitors Comment Organism Structure
2-(2-fluorobiphenyl-4-yl)-N-(2-(3-methylpyridin-2-ylamino)-2-oxoethyl)propanamide
-
 Rattus norvegicus
2-(2-fluorobiphenyl-4-yl)-N-(3-methylpyridin-2-yl)propanamide mode of inhibition, overview. Flu-AM1 does not inhibit the enzyme from brain in vivo Rattus norvegicus
2-(6-methoxynaphthalen-2-yl)-N-(3-methylpyridin-2-yl)propanamide
-
 Rattus norvegicus
flurbiprofen
-
 Rattus norvegicus
naproxen 38% inhibition at 0.1 mM Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-arachidonoylethanolamine + H2O Rattus norvegicus
-
 arachidonic acid + ethanolamine
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P97612
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-arachidonoylethanolamine + H2O
-
 Rattus norvegicus arachidonic acid + ethanolamine
-
 ?

Synonyms

Synonyms Comment Organism
FAAH
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00044
-
 pH 7.4, 37°C Rattus norvegicus 2-(2-fluorobiphenyl-4-yl)-N-(3-methylpyridin-2-yl)propanamide
0.00074
-
 pH 7.4, 37°C Rattus norvegicus 2-(6-methoxynaphthalen-2-yl)-N-(3-methylpyridin-2-yl)propanamide
0.017
-
 pH 7.4, 37°C Rattus norvegicus 2-(2-fluorobiphenyl-4-yl)-N-(2-(3-methylpyridin-2-ylamino)-2-oxoethyl)propanamide
0.029
-
 pH 7.4, 37°C Rattus norvegicus flurbiprofen