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Literature summary for 3.5.1.99 extracted from

  • Lever, I.J.; Robinson, M.; Cibelli, M.; Paule, C.; Santha, P.; Yee, L.; Hunt, S.P.; Cravatt, B.F.; Elphick, M.R.; Nagy, I.; Rice, A.S.
    Localization of the endocannabinoid-degrading enzyme fatty acid amide hydrolase in rat dorsal root ganglion cells and its regulation after peripheral nerve injury (2009), J. Neurosci., 29, 3766-3780.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
URB597
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
anandamide + H2O Rattus norvegicus
-
 arachidonic acid + ethanolamine
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 adult male Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
dorsal root ganglion L4 and L5 Rattus norvegicus
-
additional information culturing does not induce major changes in FAAH expression in primary sensory neurons Rattus norvegicus
-
nerve peripheral Rattus norvegicus
-
neuron primary sensory, FAAH is localized in the soma, in small dorsal root ganglion neurons Rattus norvegicus
-
sciatic nerve
-
 Rattus norvegicus
-
spinal cord
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
anandamide + H2O
-
 Rattus norvegicus arachidonic acid + ethanolamine
-
 ?

Synonyms

Synonyms Comment Organism
endocannabinoid-degrading enzyme
-
 Rattus norvegicus
FAAH
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus injury to peripheral nerves induces changes in FAAH expression pattern in dorsal root ganglion, while inflammation of peripheral tissues does not induce changes in the FAAH expression pattern, overview additional information

General Information

General Information Comment Organism
physiological function FAAH is a degradative enzyme for a group of endogenous signaling lipids that includes anandamide, that acts as an endocannabinoid and an endovanilloid by activating cannabinoid and vanilloid type 1 transient receptor potential,TRPV1, receptors, respectively, on dorsal root ganglion sensory neurons. Inhibition of FAAH activity increases anandamide concentrations in nervous tissue and reduces sensory hypersensitivity in animal pain models Rattus norvegicus