Literature summary for 3.5.1.99 extracted from

Karbarz, M.J.; Luo, L.; Chang, L.; Tham, C.S.; Palmer, J.A.; Wilson, S.J.; Wennerholm, M.L.; Brown, S.M.; Scott, B.P.; Apodaca, R.L.; Keith, J.M.; Wu, J.; Breitenbucher, J.G.; Chaplan, S.R.; Webb, M.
Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase (2009), Anesth. Analg., 108, 316-329.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
4-(3-phenyl-[1,2,4]thiadiazol-5-yl)piperazine-1-carboxylic acid phenylamide	-	Homo sapiens
4-(3-phenyl-[1,2,4]thiadiazol-5-yl)piperazine-1-carboxylic acid phenylamide	JNJ-1661010	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q6GMR7	-	-
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
arachidonoyl ethanolamide + H2O	-	Rattus norvegicus	arachidonic acid + ethanolamine	-	?
arachidonoyl ethanolamide + H2O	-	Homo sapiens	arachidonic acid + ethanolamine	-	?
oleoyl ethanolamide + H2O	-	Rattus norvegicus	oleic acid + ethanolamine	-	?
oleoyl ethanolamide + H2O	-	Homo sapiens	oleic acid + ethanolamine	-	?

Synonyms

Synonyms	Comment	Organism
fatty acid amide hydrolase	-	Rattus norvegicus
fatty acid amide hydrolase	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00001	-	JNJ-1661010, without preincubation	Rattus norvegicus	4-(3-phenyl-[1,2,4]thiadiazol-5-yl)piperazine-1-carboxylic acid phenylamide
0.000012	-	JNJ-1661010, without preincubation	Homo sapiens	4-(3-phenyl-[1,2,4]thiadiazol-5-yl)piperazine-1-carboxylic acid phenylamide

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Release 2023.1 (January 2023)