Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate | - |
Homo sapiens | |
3'-carbamoylbiphenyl-3-yl undec-10-yn-1-ylcarbamate | - |
Homo sapiens | |
4-(benzyloxy)phenyl butylcarbamate | - |
Homo sapiens | |
7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one | - |
Homo sapiens | |
JP104 | - |
Homo sapiens | |
OL-135 | - |
Homo sapiens | |
URB532 | - |
Homo sapiens | |
URB597 | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | FAAH-2 is luminally orientated in the membrane | Homo sapiens | 16020 | - |
membrane | FAAH-1 shows a predominantly cytoplasmic orientation in the membrane | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
anandamide + H2O | Homo sapiens | FAAH-1 plays a primary role in regulating endocannabinoid signaling | ethanolamine + arachidonic acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00519 | - |
- |
Homo sapiens | Q6GMR7 | - |
- |
Mus musculus | O08914 | - |
- |
Rattus norvegicus | P97612 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
heart | highly expressed | Homo sapiens | - |
kidney | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
additional information | no activity in brain, small intestine and testis | Homo sapiens | - |
additional information | no activity in heart | Homo sapiens | - |
OVCAR-3 cell | - |
Homo sapiens | - |
prostate | - |
Homo sapiens | - |
small intestine | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
anandamide + H2O | - |
Homo sapiens | ethanolamine + arachidonic acid | - |
? | |
anandamide + H2O | FAAH-1 plays a primary role in regulating endocannabinoid signaling | Homo sapiens | ethanolamine + arachidonic acid | - |
? | |
anandamide + H2O | 5% of the activity with oleamide | Homo sapiens | ethanolamine + arachidonic acid | - |
? | |
additional information | no activity with N-oleoyltaurine | Homo sapiens | ? | - |
? | |
N-oleoylethanolamine + H2O | 23% of the activity with oleamide | Homo sapiens | oleic acid + ethanolamine | - |
? | |
N-oleoylethanolamine + H2O | 33% of the activity with anandamide | Homo sapiens | oleic acid + ethanolamine | - |
? | |
N-oleoyltaurine + H2O | 4% of the activity with anandamide | Homo sapiens | taurine + oleic acid | - |
? | |
N-palmitoylethanolamine + H2O | 12% of the activity with anandamide | Homo sapiens | palmitic acid + ethanolamine | - |
? | |
N-palmitoylethanolamine + H2O | 2.3% of the activity with oleamide | Homo sapiens | palmitic acid + ethanolamine | - |
? | |
oleamide + H2O | - |
Homo sapiens | oleic acid + NH3 | - |
? | |
oleamide + H2O | 57% of the activity with anandamide | Homo sapiens | oleic acid + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FAAH-1 | - |
Mus musculus |
FAAH-1 | - |
Rattus norvegicus |
FAAH-1 | - |
Homo sapiens |
FAAH-2 | - |
Homo sapiens |
FAAH-2 | FAAH-2 is an ancient gene present in primates, but not murids | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00000038 | - |
pH 9.0, 37°C | Homo sapiens | 3'-carbamoylbiphenyl-3-yl undec-10-yn-1-ylcarbamate | |
0.000001 | - |
pH 9.0, 37°C | Homo sapiens | JP104 | |
0.0000134 | - |
pH 9.0, 37°C | Homo sapiens | OL-135 | |
0.000206 | - |
pH 9.0, 37°C | Homo sapiens | 7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one | |
0.000283 | - |
pH 9.0, 37°C | Homo sapiens | 4-(benzyloxy)phenyl butylcarbamate | |
0.00136 | - |
pH 9.0, 37°C | Homo sapiens | URB532 |