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Literature summary for 3.5.1.98 extracted from

  • Li, H.; Torres-Garcia, J.; Latrasse, D.; Benhamed, M.; Schilderink, S.; Zhou, W.; Kulikova, O.; Hirt, H.; Bisseling, T.
    Plant-specific histone deacetylases HDT1/2 regulate GIBBERELLIN 2-OXIDASE2 expression to control Arabidopsis root meristem cell number (2017), Plant Cell, 29, 2183-2196 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene HDT1, expression analysis Arabidopsis thaliana
gene HDT2, expression analysis Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information knockdown of HDT1/2 (hdt1,2i), phenotypes. GA2ox2 expression is increased in all transit-amplifying cells in hdt1,2i-1 Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Arabidopsis thaliana 5634
-

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q56WH4
-
-
Arabidopsis thaliana Q9FVE6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information gene HDT1, expression analysis Arabidopsis thaliana
-
additional information gene HDT2, expression analysis Arabidopsis thaliana
-
root apical meristem
-
 Arabidopsis thaliana
-

Synonyms

Synonyms Comment Organism
HDT1
-
 Arabidopsis thaliana
HDT2
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction knockdown of HDT1/2 (hdt1,2i) results in an earlier switch and causes a reduced root meristem cell number. Overexpression of GA2ox2 in the RM phenocopies the hdt1,2i phenotype. Conversely, knockout of GA2ox2 partially rescues the root growth defect of hdt1,2i. The hdt1,2i-1 root tip has a gibberellin-deficient phenotype Arabidopsis thaliana
metabolism two Arabidopsis thaliana paralogues encoding plant-specific histone deacetylases, HDT1 and HDT2, regulate a second switch from transit-amplifying cells to expanding cells Arabidopsis thaliana
physiological function plant-specific histone deacetylases HDT1/2 regulate gibberellin2-oxidase2 gene expression to control Arabidopsis thaliana meristem cell number. HDT1/2 directly negatively regulate the acetylation level of the C19-gibberellin2-oxidase2 (GA2ox2) locus and repress the expression of GA2ox2 in the RM and elongation zone, transcriptome analyses. HDT1 and 2 function as part of a mechanism that modulates root growth in response to environmental factors Arabidopsis thaliana